Registration Dossier
Registration Dossier
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EC number: 425-450-9 | CAS number: 294-90-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Limit test:
- no
- Total exposure duration:
- 72 h
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Remarks:
- Biomass
- Effect conc.:
- 19 mg/L
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Remarks:
- Growth rate
- Effect conc.:
- 99 mg/L
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Remarks:
- Growth rate
- Effect conc.:
- 1.56 mg/L
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Remarks:
- Biomass
- Effect conc.:
- < 1.56 mg/L
- Conclusions:
- The toxicity parameters of test substance to Desmodesmus subspicatus (algae) were:-EC50(72h), biomass: 19 mg/L-NOEC (72h), biomass: <1.56 mg/L-EC50(72h), growth rate: 99 mg/L-NOEC (72h), growth rate: 1.56 mg/L
- Executive summary:
The toxicity to aquatic algae of test substance was performed according to the OECD 201 Guideline under GLP conditions.
Desmodesmus subspicatus were exposed to test substance for 72h. The test substance effects were evaluated based on biomass and growth rate.
The effect parameters (biomass and growth rate based) of test substance to Desmodesmus subspicatus were: EC50(72h), biomass: 19 mg/L; NOEC (72h), biomass: <1.56 mg/L; EC50(72h), growth rate: 99 mg/L; NOEC (72h), growth rate: 1.56 mg/L.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, C.3
- GLP compliance:
- yes
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Limit test:
- no
- Total exposure duration:
- 72 h
- Hardness:
- 24 mg CaCO3/L
- Nominal and measured concentrations:
- 1.0 and 10.0 mg /L, a decrease of the nominal concentration was detected after 72 h, which was less than 20%. Nominal values were used
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Remarks:
- Biomass
- Effect conc.:
- 0.6 mg/L
- Nominal / measured:
- nominal
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Remarks:
- Growth rate
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- nominal
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Remarks:
- Growth rate
- Effect conc.:
- 0.01 mg/L
- Nominal / measured:
- nominal
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Remarks:
- Biomass
- Effect conc.:
- 0.01 mg/L
- Nominal / measured:
- nominal
- Conclusions:
- The toxicity parameters(growth rate and biomass based) of test substance to Pseudokirchnerella subcapitata were:-EC50(72h), biomass: 0.6 mg/L-NOEC (72h), biomass: 0.01 mg/L-EC50(72h), growth rate: 1.7 mg/L-NOEC (72h), growth rate: 0.01 mg/L
- Executive summary:
The toxicity to aquatic algae of test substance was performed according to the 92/69/EWG, C.3 Guideline under GLP conditions.
Pseudokirchnerella subcapitata were exposed to test substance for 72h. The test substance effects were evaluated based on biomass and growth rate.
The effect parameters of test substance to Desmodesmus subspicatus were: EC50(72h), biomass: 0.6 mg/L; NOEC (72h), biomass: 0.01 mg/L; EC50(72h), growth rate: 1.7 mg/L; NOEC (72h), growth rate: 0.01 mg/L.
Referenceopen allclose all
Stock solution was analyzed for ZK 482803 by DOC measurement; test concentrations were extrapolated.
Description of key information
Toxicity to aquatic algae and cyanobacteria. Key study(001).Test method according to OECD 201. GLP study.Desmodesmus subspicatuswere exposed to test substance for 72h. The test substance effects were evaluated based on biomass and growth rate.
The effect parameters (biomass and growth rate based) of test substance to Desmodesmus subspicatuswere: EC50(72h), biomass: 19 mg/L; NOEC (72h), biomass: <1.56 mg/L; EC50(72h), growth rate: 99 mg/L; NOEC (72h), growth rate: 1.56 mg/L.
Toxicity to aquatic algae and cyanobacteria. Key study(002). Test method according to 92/69/EWG, C.3, comparable to guideline with acceptable restrictions. GLP study.Pseudokirchnerella subcapitatawere exposed to test substance for 72h. The test substance effects were evaluated based on biomass and growth rate.
The effect parameters of test substance to Desmodesmus subspicatuswere: EC50(72h), biomass: 0.6 mg/L; NOEC (72h), biomass: 0.01 mg/L; EC50(72h), growth rate: 1.7 mg/L; NOEC (72h), growth rate: 0.01 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 19 mg/L
- EC10 or NOEC for freshwater algae:
- 1.56 mg/L
Additional information
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