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EC number: 443-860-6 | CAS number: 302776-68-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation (OECD TG 404, GLP): not irritating
Eye irritation (OECD TG 405, GLP): not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
Two skin irritation studies according OECD TG 404 and GLP were conducted with two specifications of Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate:
The key study (BASFAG18H0636/022173) used the test substance as pasty melt, representing the currently manufactured product.
Additional study (BASFAG18H0408/992237) used the test substance in cristalline form.
In both studies 3 young adult New Zealand white rabbits (males and females) were exposed to 5 mL and 5 g (moistened with aqua bidest) of the test substance in the key study and in the supporting study respectively. Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate was applied on a patch of 2.5 cm x 2.5 cm in a semiocclusive dressing for 4 hours. After the 4 hours exposure time, the test substance was washed of and the animals were observed for 7 days after removal of the patch in the key study.
Irritation was scored according to the EU method B.5 and the OECD 405 guideline. The average irritation scores (including all relevant observation timepoints and animals tested) were as follows:
- key study: 1.3 for erythema and 0.0 for edema
- additional study: 0.1 for erythema and 0.0 for edema.
The cutaneous reactions observed in the key study (reversible within 7 days), were based on a secondary effect, beeing related to a prolonged exposure period due to residuals/ adhesive remains of the test substance which were still found after subsequent washing at the time points when the skin reactions were assessed (1, 24, 48, 72 hours and 7 days). The other study results support this assumption since no remains of test substance were found, leading to lower erythema scores.
In line, repeated dermal application of Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate (20 or 10%) on guinea pigs showed no more severe skin reactions than observed after application of the respective vehicle (BASFAG99H0636/02074).
Taken together, the average erythema scores (< 2) in addition to the edema scores in both studies (0) provide evidence for the absence of a signficant dermal irritation potential of Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate.
Eye irritation:
Two eye irritation studies according to OECD 405 and GLP were conducted with Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate.
BASFAG11H0636/022174 was selected as the key study because the used test substance specification, i.e. pasty melt, represents the currently manufactured product.
In the additional study (BASFAG11H0408/992236) the crystalline form of Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate was applied directly to the eye.
Both studies showed comparable results:
In the key study, the test substance (melted for volume determination, i.e. 0.1 mL and subsequent cooling down) was instilled into the conjunctival sac of the right eye of young adult New Zealand White rabbits (2 males, 1 female) for 24 hours. The substance was rinsed with water after 24 hours. Animals then were observed for 72 hours. Irritation was scored by EU Method B.5 and OECD Method 405. The average score (including all relevant observation timepoints and animals tested) for eye irritation was as follows:
- key study: 0.0 for corneal opacity and for iris, 0.1 for conjunctival redness and 0.0 for chemosis
- additional study: 0.0 for corneal opacity and for iris, 0.3 for conjunctival redness and 0.0 for chemosis
Taken together, the present data
provide evidence for the absence of a significant eye irritation
potential of Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate.
Justification for classification or non-classification
The present data on skin and eye irritation do not fulfill the criteria laid down in 67/548/EEC and 1272/2008/EEC, and therefore, a non-classification is warranted.
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