Registration Dossier
Registration Dossier
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EC number: 826-544-6 | CAS number: 29118-25-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
For acute toxicity (EC50, LC50) in D. magna, the VEGA/COMBASE and VEGA/IRFMN models provide predictions for the target compound of 107.95 mg/l (EC50) and 5.97 mg/l (EC50), respectively, associated with a low reliability mainly due to the lack of similar compounds. Similarly, the VEGA/DEMETRA and VEGA/EPA models provide predictions of 9.25 mg/l (LC50) and 40.86 mg/l (LC50), respectively, associated with a low reliability.
With regard to chronic toxicity in D. magna, the VEGA/IRFMN predicts 1.43 mg/l of NOEC for the compound of concern, reporting low reliability and ADI= 0.237. In all the cases, the ADI is < 0.45.
Overall assessment. The predictions for acute toxicity resulting from VEGA/COMBASE and VEGA/IRFMN models (EC50) are contradictory and not associated to the necessary reliability to provide a definite assessment. However, results from VEGA/DEMETRA and VEGA/EPA models can
provide a more defined assessment, possibly assuming a LC50 between 9.25 - 40 mg/l. Similarly, the predicted value for NOEC = 1.43 seems to be in line with acute contact toxicity effects, thus it should be taken into account for chronic toxicity effects.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 40 mg/L
Additional information
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