Registration Dossier
Registration Dossier
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EC number: 947-883-7 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Draize single insult patch test technique on the clipped intact and abraded skin of albino rabbits.
Several studies exist; in each study, 0.5 ml samples of diluted or undiluted Myristyl Myristate were applied and occluded for 24h, after which time the patch sites were evaluated for erythema and edema by the Draize technique. The sites were again graded at 72h.
The undiluted ingredient produced minimal to mild irritation. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetradecyl myristate
- EC Number:
- 221-787-9
- EC Name:
- Tetradecyl myristate
- Cas Number:
- 3234-85-3
- Molecular formula:
- C28H56O2
- IUPAC Name:
- tetradecyl myristate
- Test material form:
- solid: flakes
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml undiluted
- Duration of treatment / exposure:
- 24h
- Observation period:
- 72h
- Number of animals:
- 18
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- > 0.11 - <= 2.5
- Max. score:
- 2.5
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0.5
- Max. score:
- 1.15
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0.5
- Max. score:
- 1.15
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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