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EC number: 403-140-4 | CAS number: 103694-68-4 MAJANTOL; MAJANTOL R
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance contact dermatitis – a worldwide multicenter investigation (Part III)
- Author:
- Larsen, W. et al.
- Year:
- 2 002
- Bibliographic source:
- Contact Dermatitis, 46, 141-144
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Patch test methods and readings were conducted according to internationally accepted criteria (Fischer & Maibach, 1984; Nethercott, 1991) and involved the Finn Chamber patch test technique.
- Short description of test conditions: 218 fragrance-sensitive volunteers were evaluated for skin reactions after exposure to the test substance for 2-3 days. Additional readings were done 2 - 5 days after first reading.
- Parameters analysed / observed: skin reaction after application of the test substance
Fischer T., Maibach H. I. (1984) Finn Chamber patch test technique. Contact Derm 1984: 11: 137–140.
Nethercott J. R. et al. (1991) Patch testing with a routine screening tray in North America 1985–1989. I. Frequency of response. Am J Contact Dermatitis 1991: 2: 122–129. - GLP compliance:
- no
Test material
- Reference substance name:
- 3-(2,2-dimethyl-3-hydroxypropyl)toluene
- EC Number:
- 403-140-4
- EC Name:
- 3-(2,2-dimethyl-3-hydroxypropyl)toluene
- Cas Number:
- 103694-68-4
- Molecular formula:
- C12H18O
- IUPAC Name:
- 2,2-dimethyl-3-(3-methylphenyl)propan-1-ol
Constituent 1
Method
- Type of population:
- other: patients with proven contact dermatitis due to fragrance materials
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 217
- Sex: 85.3% females and 14.3% males
- Age: 46.3 ± 14.7
- Demographic information: Volunteers were tested in Japan, Northern Ireland, United States, England, Germany, Switzerland and Sweden. The majority of the subjects were Caucasian. - Clinical history:
- - History of allergy or casuistics for study subject or populations: All patients had proven contact dermatitis due to fragrance materials. Facial eruptions (28.0%) and hand (26.1%) and neck (10.6%) involvement were the most common location for eczematous dermatitis. Alll patients were free of eczema.
- Exposure history: Volunteers had proven sensitization to at least one fragrance material established by previous patch tests to fragrance allergens.
- Any other allergic or airway disorders: Many patients reported a personal history of hay fever, asthma or atopic dermatitis. - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: not specified
- Description of patch: Finn patch
- Concentrations: undiluted
- Testing/scoring schedule: The patch test sites were evaluated initially at 2 - 3 days. The sites were reexamined in the majority of cases, usually between 2 and 5 days after the 1st reading.
EXAMINATIONS
- Grading/Scoring system: not specified
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed: 3.2% positive response in 217 patients
Applicant's summary and conclusion
- Conclusions:
- In this human patch test in patients with proven contact dermatitis due to fragrance materials, the undiluted test substance induced sensitisation in 3.2% of 217 patients. Therefore, the test substance is regarded as skin sensitising.
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