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Diss Factsheets
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EC number: 904-908-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
EPI-SUITE EPA (USA)
2. MODEL (incl. version number)
BIOWIN 4.10
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
SMILES : O=C(OCC(CC)C)c(c(O)ccc1)c1
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The QMRF is available in "Attached justification".
5. APPLICABILITY DOMAIN
The QPRF is available in “Attached justification”.
6. ADEQUACY OF THE RESULT
The QPRF is available in “Attached justification”. - Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Howard, P.H., Boethling, R.S., Stiteler, W.M., Meylan, W.M., Hueber, A.E., Beauman, J.A., Larosche, M.E. 1992. Predictive model for aerobic biodegradability developed from a file of evaluated biodegradation data. Environ. Toxicol. Chem. 11:593-603.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: O=C(OCC(CC)C)c(c(O)ccc1)c1
- Key result
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The substance is predicted to be readily biodegradable (EPISUITE, BIOWIN v4.10).
- Executive summary:
The substance is predicted to be readily biodegradable (EPISUITE, BIOWIN v4.10).
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 1st, 1978 to August 4th, 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- yes
- Remarks:
- 14 day test
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Concentration of sludge: 30 mg/L
- Duration of test (contact time):
- 2 wk
- Initial conc.:
- 100 mg/L
- Based on:
- not specified
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Remarks:
- (GC, direct analysis)
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- BOD (Indirect analysis)
- Details on study design:
- TEST CONDITIONS
- Test temperature: 25ºC
- pH: 7.0
- pH adjusted: yes
- Suspended solids concentration: 30 mg/l
TEST SYSTEM
- Number of culture flasks/concentration: 2
- Measuring equipment: respirometer, TOC analtser (Coulometric detections)
- Test performed in closed vessels due to significant volatility of test substance: no
CONTROL AND BLANK SYSTEM
- Inoculum blank: 30 mg/l sludge in medium
- Abiotic sterile control: medium + 100 mg/l
- Toxicity control: no
- Reference substance:
- aniline
- Remarks:
- (100 mg/L)
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 83.4
- Sampling time:
- 2 wk
- Remarks on result:
- other: (indirect analysis)
- Key result
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 100
- Sampling time:
- 2 wk
- Remarks on result:
- other: (GC, direct analysis)
- Results with reference substance:
- Degree of decomposition of aniline (7 days): 72.4%
- Validity criteria fulfilled:
- yes
- Remarks:
- The difference between replicates has to be <20%. Aniline degradation has to be >40% after 70 days, if the O2 uptake us <50 mg/L (the test was for 14 d not 28 but O2 consumption was really low (2.3mg/L) compared to 60 mg/l.
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test item was determined to be readily biodegradable (BOD=83.4%, Degradation=100%) under test conditions.
- Executive summary:
The ready biodegradability test was performed by MITI according to OECD Guideline 301 C. Activated sludge (30 mg/L) were exposed to test item (100 mg/L) under aerobic conditions for 2 weeks. The biodegradation was analysed by indirect analysis (BOD) and direct analysis (GC). The percentages of degradation were determined to be 83.4% based on oxygen consumption and 100% based on GC. Based on these results, the test substance was determined to be readily biodegradable.
Referenceopen allclose all
Biowin1 (Linear Model) : 0.9384
Biowin2 (Non-Linear Model) : 0.9936
Expert Survey Biodegradation Results:
Biowin3 (Ultimate Survey Model): 2.9355 (weeks)
Biowin4 (Primary Survey Model): 3.8159 (days)
MITI Biodegradation Probability:
Biowin5 (MITI Linear Model) : 0.5824
Biowin6 (MITI Non-Linear Model): 0.6741
Anaerobic Biodegradation Probability:
Biowin7 (Anaerobic Linear Model): 0.4339
Ready Biodegradability Prediction: YES
Description of key information
Based on the individual biodegradabilities of the main constituents, the test item is deemed readily biodegradable.
Key study: Isopentyl salicylate. OECD 301C. Activated sludge (30 mg/L) were exposed to test item (100 mg/L) under aerobic conditions for 2 weeks. The biodegradation was analysed by indirect analysis (BOD) and direct analysis GC, obtaining a biodegradation of 83.4 and 100% respectively. Based on these results the substance was determined to be readily biodegradable.
Key study: 2 -methylbutyl salicylate. Estimation by EPISUITE, BIOWIN v4.10. The substance is predicted to be readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Based on the information provided by the individual biodegradabilities of the two components of the test item. The substance reaction mass of isopentyl salicylate and 2 -methylbutyl salicylate is determined to be readilly biodegradable.
The ready biodegradability test of Isopentyl salicylate was performed by MITI according to OECD Guideline 301 C. Activated sludge (30 mg/L) were exposed to test item (100 mg/L) under aerobic conditions for 2 weeks. The biodegradation was analysed by indirect analysis (BOD) and direct analysis (GC), obtaining a biodegradation of 83.4 and 100% respectively. Based on these results, the test substance was determined to be readily biodegradable.
2 -methylbutyl salicylate was also predicted to be readily biodegradable using EPISUITE, BIOWIN v4.10.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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