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EC number: 262-810-2 | CAS number: 61477-95-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Justification for type of information:
- Read-across justification is provided in Appendix 3 of the CSR.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- ISO 8692 (Water Quality - Fresh Water Algal Growth Inhibition Test with Scenedesmus subspicatus and Selenastrum capricornutum)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Name of test material (as cited in study report): Methylparaben
- Analytical monitoring:
- not specified
- Details on sampling:
- no data
- Vehicle:
- no
- Details on test solutions:
- no data
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- no data
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Post exposure observation period:
- no data
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- Nominal concentrations: 2, 5, 10, 20, 50, 100, 200 mg/L measured concentrations: no data
- Details on test conditions:
- TEST SYSTEM
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 6
TEST MEDIUM
Exponentially growing batch cultures of algae were exposed to a serial dilution of the test substance. The test was incubated on a shaking table under constant temperature and light.
EFFECT PARAMETERS MEASURED:
The cell densities were determined by fluoremetric measurement after 24, 48, and 72 hours of exposure. The inhibition of growth at each test concentration was determined as the average growth rate in per cent of the control growth rate.
The concentrations, which inhibited the growth rate 10 and 50%, were calculated by use of a computer program ‘Toxedo’ (VKI 1992). The highest concentration at which no significant effect was observed (No Observed Effect Concentration, NOEC), was determined by Dunnett’s procedure (US-EPA 1989). - Reference substance (positive control):
- no
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 31 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% CL: 29-32 mg/L
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 91 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% CL: 90-93 mg/L
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: -
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 20 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: -
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The toxicity to aquatic algae (Pseudokirchneriella subcapitata) was determined in a study based on a ISO guideline and the EC50 after 72 hours was determined to be 91 mg/L.
- Executive summary:
The toxicity to aquatic algae (Pseudokirchneriella subcapitata) was determined in a study based on a ISO guideline and the EC50 after 72 hours was determined to be 91 mg/L.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The calculation was using the scientific acceptable software program as recommended in REACH Guideline R.6 under REACH Regulation (EC) No 1907/2006.
SMILES (used for QSAR prediction): C(=O)(O)c1ccc(S(=O)(O)=NCl)cc1
ID of substance (used for QSAR prediction)
EC Number 262-810-2 Registry Number 61477-95-0 PubChem CID
Chemical Name monalazone disodium
Molecular Formula C7 H6 CL1 N1 O4 S1 Molecular weight (g/mole) 235.64 - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Deviations:
- not specified
- GLP compliance:
- no
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 342.051 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: Battery
- Basis for effect:
- not specified
- Remarks on result:
- other: Domain: IN
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 109.126 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: Leadscope
- Basis for effect:
- not specified
- Remarks on result:
- other: Domain: IN
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The calculation was using the scientific acceptable software program as recommended in REACH Guideline R.6 under REACH Regulation (EC) No 1907/2006.
SMILES (used for QSAR prediction): C(=O)(O)c1ccc(S(=O)(O)=NCl)cc1
ID of substance (used for QSAR prediction)
EC Number 262-810-2 Registry Number 61477-95-0 PubChem CID
Chemical Name monalazone disodium
Molecular Formula C7 H6 CL1 N1 O4 S1 Molecular weight (g/mole) 235.64 - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Deviations:
- not specified
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 303 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- other: ECOSAR Classes: Amides -acid
- Basis for effect:
- growth rate
- Remarks on result:
- other: Most Toxic Class: Amides -acid. Max. Log Kow for Most Toxic Class: >8
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 512.181 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: Neutral Organic SAR
Referenceopen allclose all
Statistical parameters calculated from continuous responses based on continuous mean.
Test type : Growth Inhibition Test.
6 doses and 13 responses have been used during calculations.
Concentration | Growth | Inhibition |
in mg/L | [%] | |
Control values |
||
Control 1 | 2.102 | - |
Control 2 | 2.094 | - |
Control 3 | 2.101 | - |
Control 4 | 2.123 | - |
Control 5 | 2.118 | - |
Control 6 | 2.102 | - |
Control mean | 2.107 | 0 |
Experimental data | ||
2 | 2.046 | 2.9 |
2 | 2.129 | 0.0 |
2 | 2.086 | 1.0 |
5 | 2.129 | 0.0 |
5 | 2.109 | 0.0 |
5 | 2.093 | 0.6 |
10 | 2.151 | 0.0 |
10 | 2.132 | 0.0 |
10 | 2.029 | 3.7 |
20 | 2.108 | 0.0 |
20 | 2.114 | 0.0 |
20 | 2.137 | 0.0 |
50 | 1.836 | 12.8 |
50 | 1.820 | 13.6 |
50 | 1.779 | 15.6 |
100 | 0.917 | 56.5 |
100 | 0.908 | 56.9 |
100 | 0.908 | 56.9 |
200 | 0.337 | 84.0 |
200 | 0.337 | 84.0 |
200 | 0.341 | 83.8 |
Description of key information
Testing to aquatic algae and cyanobacteria was considered not necessary as alternatives to testing were available and they demonstrated to be sufficient to fulfil the requirement of Annex VII 9.1.2 on Growth inhibition study aquatic plants. Therefore, the general rules for adaption 1.2, 1,3 and 1.5 of Annex XI of REACH regulation were applied. The results obtained from QSARs models indicated the absence of hazardous to the aquatic environment and the testing with the registered substance was considered not reasonable. Furthermore, read across data from a similar substance was used as supporting information.
The following data has been taken into account for the hazard assessment:
-72h EC50: 303 mg/L (ECOSAR v1.11)
-72h EC50: 109.12 mg/L (Danish QSAR Database)
-72h EC50: 91 mg/l: NOEC: 20 mg/L: EC10: 31 mg/L (read across)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 109 mg/L
- EC50 for marine water algae:
- 109 mg/L
- EC10 or NOEC for freshwater algae:
- 109 mg/L
- EC10 or NOEC for marine water algae:
- 109 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.