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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: techniques specified in the Federal Insecticide, Fungicide, and Rodenticide Act (40 CFR 163).
- GLP compliance:
- no
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
- Molecular formula:
- C32H16N8Co(SO3)n with n=0 to 3
- IUPAC Name:
- Reaction mass of Trihydrogen [29H,31H-phthalocyaninetrisulphonato(5-)-N29,N30,N31,N32]cobaltate(3-) and [29H,31H-phthalocyaninato-N29,N30,N31,N32]cobalt and dihydrogen [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cobaltate(2-) and hydrogen [29H,31H-phthalocyaninesulphonato(3-)-N29,N30,N31,N32]cobaltate(1-)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: weight range for the male rats was 200 to 257 grams and for the female rats was 200 to 230 grams.
- Diet (e.g. ad libitum): ad libidum
- Water (e.g. ad libitum): ad libidum
- Acclimation period: 6 day prior to dosing
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12hrs dark/ 12 hrs light
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- Except for one screening procedure which has been carried out with corn oil
- Details on oral exposure:
- Screening procedure in distilled water : The sample was administered as a 25.0% w/v solution in distilled water at a dosage level of 5.0 grams per kilogram of body weight.
Screening procedure in corn oil : rats was 237 to 261 grams and for the female rats was 217 to 238 grams. The sample was administered as a 25.0 % w/v solution in corn oil at a dosage level of 5.0 grams per kilogram of body weight.
Median lethal dosage determination in distilled water : The sample was administered as a 50,0% w/v solution in distilled water at dosage levels of 1.0, 2.0, 4.0, and 8.0 grams per kilogram of body weight. - Doses:
- Screening procedure in distilled water : The sample was administered as a 25.0% w/v solution in distilled water at a dosage level of 5.0 grams per kilogram of body weight.
Screening procedure in corn oil : rats was 237 to 261 grams and for the female rats was 217 to 238 grams. The sample was administered as a 25.0 % w/v solution in corn oil at a dosage level of 5.0 grams per kilogram of body weight.
Median lethal dosage determination in distilled water : The sample was administered as a 50,0% w/v solution in distilled water at dosage levels of 1.0, 2.0, 4.0, and 8.0 grams per kilogram of body weight. - No. of animals per sex per dose:
- 5 per sex and per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
All animals were observed closely for gross signs of systemic toxicity and mortality at three-quarter to two and onequarter, three and one-quarter to four and one-half, and four and one-quarter to five and three-quarter hours during the day of dosing, and twice daily (except days 2 and 3) thereafter for a total of 14 days. The rats were not weighed individually on the seventh postdosing day in deviation from the protocol.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 700 mg/kg bw
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 600 mg/kg bw
- Mortality:
- 5 g/kg, distilled water : all animals died
5 g/kg, corn oil : 7 animals died
1g/kg : no death
2 g/ kg : 1 female died
4 g/ kg : 3 males and 1 female died
8 g/kg : all animals died - Clinical signs:
- other: nine females from the 1.0 and 4.0 g/kg dosage levels which showed sample colored diarrhea or feces.. Sample staining of the tail and/or anus was observed in most surviving male and female rats from all dosage groups. Central nervous system depression was
- Gross pathology:
- nine females from the 1.0 and 4.0 g/kg dosage levels which showed sample colored diarrhea or feces.. Sample staining of the tail and/or anus was observed in most surviving male and female rats from all dosage groups.
Central nervous system depression was observed at the two higher dosages in males and the highest level in females during the first week of the observation period.
Sporadic abnormalities noted in a few rats at the higher dosages (4.0 or 8.0 g/kg) included humped-back posture (male, female), piloerection (male, female), slight emaciation (male), nasal discharge (male),
comatose behavior (male), decreased locomotor activity (female), and squinted eyes (female).
Necropsies of all eight males and most of the seven females revealed stomachs and intestines which were either sample stained or contained sample-colored contents. An external abnormality observed in most animals was sample staining of the fur over most of the body including extre.mifcies, mouths, and anuses. Diarrhea stains around the anuses of three females and one male were noted. Two male rats appeared cannibalized by the time of necropsy. Bloated stomachs were observed in four males and two females. Autolysis was noted in three males and two females. Most rats of either sex had congested or darkened kidneys and several had pale livers.
One male and one female rat (2.0 g/kg level) exhibited hollow right and/or left kidneys. The same female rat had a growth on the right kidney, which was not considered drug-related.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Under the tests conditions, the test item has a oral LD50 of 3.6 g/kg in male rats and 3.7 g/kg female rats. According to GHS criteria, the test item is classified as Acute toxicity oral category 5.
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