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Diss Factsheets
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EC number: 701-149-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well-documented study report which meets basic scientific principles.
Data source
Referenceopen allclose all
- Title:
- Gasoline vapour exposures. Part I. Characterisation of workplace exposures.
- Author:
- Halder CA, et al.
- Year:
- 1 986
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 47:164-172.
- Title:
- Neuropsychological Symptoms Among Tanker Drivers with Exposure to Solvents
- Author:
- Hakkola M
- Year:
- 1 994
- Bibliographic source:
- Occup. Med. 44:243-246.
- Title:
- Neuropsychological Symptoms Among Tanker Drivers Exposed to Gasoline
- Author:
- Hakkola M, Honkasalo M-L, Pulkkinen P
- Year:
- 1 996
- Bibliographic source:
- Occup. Med. 46(2):125-130.
- Title:
- Changes in Neuropsychological Symptoms and Moods Among Tanker Drivers exposed to Gasoline During a Work Week
- Author:
- Hakkola M, Honkasalo ML, Pulkkinen P
- Year:
- 1 997
- Bibliographic source:
- Occup. Med. 47(6):344-348.
- Title:
- Exposure of Tanker Drivers to Gasoline and Some of Its Components
- Author:
- Hakkola M, Saarinen L
- Year:
- 1 996
- Bibliographic source:
- Ann. Occup. Hyg. 40(1):1-10.
- Title:
- Behavioral studies in petrol pump workers
- Author:
- Kumar P, Gupta K, Clerk S
- Year:
- 1 988
- Bibliographic source:
- International Archives of Occupational and Environmental Health 61:35-38.
- Title:
- Occupational exposure of petrol pump workers
- Author:
- Pandya K, Rao G, Dhasmana A, Zaidi S
- Year:
- 1 975
- Bibliographic source:
- Annals of Occupational Hygiene 18:363-364.
- Title:
- An investigation of environmental impact on health of workers at retail petrol pumps
- Author:
- Das M, Bhargava SK, Kumar A. et al.
- Year:
- 1 991
- Bibliographic source:
- Ann Occup Hyg 35(3):347-352.
Materials and methods
- Type of study / information:
- Type of experience: Human
Results and discussion
Applicant's summary and conclusion
- Executive summary:
These studies do not provide useful data for risk assessment purposes, given that the authors provided no quantitative exposure-response analyses that could be used to generate a NOAEL. Moreover, the overall findings do not suggest substantive neurological effects at the ambient gasoline/benzene concentrations typically experienced by European or US fuel handlers. The symptom distributions reported in the Scandinavian studies are compatible with random chance, given that there are generally few statistically significant findings among multiple exploratory analyses. This is consistent with the relatively low-level and sporadic nature of the gasoline exposure in these studies. However, it is important to remember that symptoms are a relatively crude and insensitive metric for estimating neurobehavioral effects.
Studies of Indian fuel handlers reported increased symptoms and poorer neurological test results than unexposed controls, but these workers experienced relatively high levels of gasoline vapors, with benzene concentrations exceeding 10 ppm in many instances. Das et al. (1991) reported a wide range of symptoms associated with petrol station employees, including non-neurologic effects such as throat congestion and bleeding gums, suggesting possible exposure to toxicants other than solvents. Also, some of these Indian workers had been exposed for up to 35 years, suggesting the possibility of neurological impact from recent or historical lead exposure.
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