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EC number: 245-322-4 | CAS number: 22914-58-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Deviations:
- yes
- Remarks:
- Minor deviations in relation to temperature, media carbon content and pH.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: Transformation/dissolution test
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- >= 9.84 - <= 11.2 mg/L
- Element analysed:
- Zinc
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- The screening test was performed across the pH range 5.5 to 8.5 to ensure that the concentration of the dissolved metal ions in solution is maximized. This test served as a preliminary screening to assess the pH that maximizes the transformation/dissolution for the full test.
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- >= 12.6 - <= 16.9 mg/L
- Element analysed:
- Molybdenum
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- The screening test was performed across the pH range 5.5 to 8.5 to ensure that the concentration of the dissolved metal ions in solution is maximized. This test served as a preliminary screening to assess the pH that maximizes the transformation/dissolution for the full test.
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 0.14 mg/L
- Element analysed:
- Zinc
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- The vessels were stoppered and shaken at approximately 100 rpm for the specified times at 25 °C ± 2°C in the dark.
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 1.86 mg/L
- Element analysed:
- Zinc
- Loading of aqueous phase:
- 10 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- The vessels were stoppered and shaken at approximately 100 rpm for the specified times at 25 °C ± 2°C in the dark.
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 13.4 mg/L
- Element analysed:
- Zinc
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- The vessels were stoppered and shaken at approximately 100 rpm for the specified times at 25 °C ± 2°C in the dark.
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 0.23 mg/L
- Element analysed:
- Zinc
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 28 d
- Test conditions:
- The vessels were stoppered and shaken at approximately 100 rpm for the specified times at 25 °C ± 2°C in the dark.
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 0.36 mg/L
- Element analysed:
- Molybdenum
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- The vessels were stoppered and shaken at approximately 100 rpm for the specified times at 25 °C ± 2°C in the dark.
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 3.47 mg/L
- Element analysed:
- Molybdenum
- Loading of aqueous phase:
- 10 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- The vessels were stoppered and shaken at approximately 100 rpm for the specified times at 25 °C ± 2°C in the dark.
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 31.1 mg/L
- Element analysed:
- Molybdenum
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- The vessels were stoppered and shaken at approximately 100 rpm for the specified times at 25 °C ± 2°C in the dark.
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- 0.35 mg/L
- Element analysed:
- Molybdenum
- Loading of aqueous phase:
- 1 mg/L
- Incubation duration:
- 28 d
- Test conditions:
- The vessels were stoppered and shaken at approximately 100 rpm for the specified times at 25 °C ± 2°C in the dark.
- Details on results:
- Screening test:
It was observed that there was variance in the zinc and molybdenum concentrations in the test solutions. However it was not considered significant and there was no obvious trend. In addition the actual pH of the test solutions after addition of the test item were all approximately neutral and in the pH range of 6.3 to 7.2.
It was therefore considered appropriate to perform the main test using ISO 6341 aqueous media unadjusted (nominal pH 8).
Validation:
The calibration curves for the analyses were second order. The concentrations of each analyte in the sample solutions were interpolated from the respective calibration curve for each analysis.
Reproducibility data obtained for the zinc and molybdenum analyses were acceptable using the pH 6 aqueous media. This demonstrated that inter-vessel variation is <10% for both zinc and molybdenum, indicating that duplicate samples from triplicate vessels is sufficient to give a representative result for the main test. - Conclusions:
- The transformation/dissolution of the test substance in terms of solubility was demonstrated to be loading rate dependant. The results for Zinc in the short-term test ranged from 0.14 to 13.4 mg/L and for Molybdenum 0.36 to 31.1 mg/L. In the long term test this was 0.23 and 0.35 mg/L, for Zinc and Molybdenum, respectively.
Reference
Discussion:
The ISO 6341 aqueous media used in the main test was analyzed for total organic carbon. It was determined to be greater than the limit specified in the test guidelines (2.0 mg/L). However, it was not considered to interfere with the analysis of zinc or molybdenum and therefore was not considered to have a significant impact on the performance of the test. The dissolved oxygen level in all the test solutions was greater than 70% saturation (>6.0 mg/L) and thus satisfied the guidelines.
The specified test temperature was 25 ± 2 °C. In the screening test , a maximum temperature of 28.0 °C was observed and several flasks were greater than 27 °C. The flasks were shaken in an controlled environment set at a nominal 25 °C; those flasks at temperatures >27 °C were shaken on flat-bed shakers which may have increased the temperature over a period of time. However, sampling was performed at ambient laboratory temperature, allowing the test
solutions to equilibrate prior to filtration; therefore the small rise in test temperature was not considered to have had a significant effect. In main test, air shakers set at 25 °C were used and the temperature remained constant (± 1 °C) over the duration of the test.
The ISO 6341 aqueous media for the screening tests at pH 5.5, 6.0, 7.0 and 8.5 were prepared at lower concentrations than are specified in the guidelines. The results indicated that there was no significant effect of pH on concentration levels over the range tested. Since there was no observed pH effect, the main test was performed using ISO 6341 aqueous media (pH unadjusted) at a nominal pH 8.
The pH of the main test solutions (7 day and 28 day) were observed to decrease. The guidelines state that the pH should be stable to <0.2 pH unit although variations in pH may be expected at higher loading rates. Since the concentrations of dissolved zinc an molybdenum were not considered to be affected by pH, the decrease in pH over the test period was not deemed significant.
The rates of increasing concentration of zinc and molybdenum in the aqueous media were observed to decrease over the 7 day testing period. However, the kinetics of the transformation/dissolution could not be calculated accurately as the results indicated that the mechanism did not follow a simple relationship. The final mean concentration of zinc and molybdenum at the end of the specified testing period has been reported.
The transformation/dissolution of the test item in terms of solubility was demonstrated to be loading rate dependent.
Description of key information
The transformation/dissolution of the test substance in terms of solubility was demonstrated to be loading rate dependant. The results for Zinc in the short-term test ranged from 0.14 to 13.4 mg/L and for Molybdenum 0.36 to 31.1 mg/L. In the long term test this was 0.23 and 0.35 mg/L, for Zinc and Molybdenum, respectively.
As the parameter of water solubility is less relevant for an inorganic substance and as various values were obtained under different conditions, no value is selected as the key value for chemical safety assessment.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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