Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-145-4 | CAS number: 78-81-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- data published in 1941
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- Hydrogen Bonding and the Solubility of Alcohols and Amines in Organic Solvents
- Author:
- Copley M.J., Ginsberg E., Zellhoefer G.F., Marvel C.S.
- Year:
- 1 941
- Bibliographic source:
- Journal of the American Chemical Society, 63, 254-256, 1941
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
The "ideal" or theoritical mole fraction solubility was calculated using Raoult's law. It is the ration of the vapor pressure of the solute at 4.5°C to its value at 32.2°C.
- Short description of test conditions: The method used in making the solubility measurements is the sames as previously described by Zellhoefer G.F. et al., Ind. Eng. Chem., 29, 548-551 (1937). Solubility measurements were made over a range of pressures at a temperature of 32.2°C. For comparative purposes, the solubitiy at a partial pressure cooresponding to the vapor pressure of the solute at 4.5°C wer ealso determined.
- Parameters analysed / observed:. Vapour pressure at 32.2°C and 4.5°C to determine solubility of the test compound in organic solvents. - GLP compliance:
- no
Test material
- Specific details on test material used for the study:
- The test substance was purified carefully by chemical mean and chemical distillation.
Results and discussion
Solubility in organic solvents / fat solubilityopen allclose all
- Medium:
- other: ethylene glycol
- Solubility:
- 0.227 other: mole fraction
- Temp.:
- 4.5 °C
- Remarks on result:
- other: theoritical mole fraction solubility
- Remarks:
- calculated using Raoult's law
- Medium:
- other: ethylene gylcol
- Solubility:
- 0.381 other: mole fraction
- Temp.:
- 4.5 °C
- Remarks on result:
- other: observed mole fraction solubility
- Test substance stable:
- not determined
Any other information on results incl. tables
Vapor pressure of the test substance at 4.5°C: 45.4 mm.
Vapor pressure of the test substance at 32.2°C: 199 mm.
Applicant's summary and conclusion
- Conclusions:
- TThe theoritical mole fraction solubility is of 0.227 as the measured one is of 0.381 in ethylene glycol. This study did not followed any guideline and lacks a lot of information regarding the experimental procedure such as temperature effects, information on chemical stability. It was considered to not be reliable.
- Executive summary:
The theoritical mole fraction solubility was calculated using Raoult's law, and is the ratio of the vapor pressure of the test substance at 4.5°C to its value 32.2°C. Additionnally, the solubility of the test substance was measured at 4.5°C using a method previously described By Zellhoefer G.F., Ind. Eng. Chem., 29, 548 -551 (1937). The theoritical mole fraction solubility is of 0.227 as the measured one is of 0.381 in ethylene glycol. This study did not followed any guideline and lacks a lot of information regarding the experimental procedure such as temperature effects, information on chemical stability. It was considered to not be reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.