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Diss Factsheets
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EC number: 246-148-1 | CAS number: 24308-84-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
in vitro, OECD 442E (hCLAT): positive
in vitro, OECD 442C (DPRA): waiving
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
A study according to OECD guideline 442C to assess key event 1 of skin sensitisation, i.e. the potential of target substance to covalent binding to skin proteins, is not feasible.
Indeed, test substance is a zinc salt and DPRA is not applicable for the testing of metal compound as they are known to react with proteins with mechanisms other than covalent binding.
A study according to OECD guideline 442E (hCLAT) to investigate key event 3 of skin sensitisation, i.e. the potential of target substance to activate monocytes and dendritic cells in the human monocytic leukemia cell line THP-1, was run. Changes in the expression of cell surface markers (CD86 and CD54) were quantified and gave a positive outcome.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
A skin sensitiser refers to a substance that will lead to an allergic response following skin contact. There is general agreement regarding the key biological events underlying skin sensitisation. The existing knowledge of the chemical and biological mechanisms associated with skin sensitisation has been summarised in the form of an Adverse Outcome Pathway (AOP), from the molecular initiating event through the intermediate events to the adverse effect, namely allergic contact dermatitis in humans or contact hypersensitivity in rodents.
Mechanistically based in chemico and in vitro test methods have been considered scientifically valid for the evaluation of the skin sensitisation hazard of chemicals. However, combinations of non-animal methods (in silico, in chemico, in vitro) within the Integrated Approaches to Testing and Assessment (IATA) will be needed to be able to fully substitute for the animal tests currently in use, given the restricted AOP mechanistic coverage of each of the currently available non-animal test methods.
As for target substance, available data is:
- key event 1: not assessable, due to substance features
- key event 2: not assessed.
- key event 3: positive
No assessment on key event 1, i.e. protein binding, could be performed as available test methods are not applicable for the testing of metal compounds. Indeed, metals are known to react with proteins via mechanisms other than covalent binding. Accordingly, an effect on proteins by the metal compound may not be excluded.
The test on key event 3 resulted to be positive; a test on key event 2 was deemed as not necessary, as a negative response would not allow to conclude that the substance is devoid of a skin sensitising potentia.
On these bases, the substance is classified as H317, i.e. substance that may cause an allergic skin reaction, according to the CLP Regulation (EC 1272/2008). Based on available data, no decision on sub-categorisation may be drawn.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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