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EC number: 220-482-8 | CAS number: 2781-11-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Jul - 16 Dec 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulations, Title 49, Part 173, Appendix II
- Version / remarks:
- 1977
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Version / remarks:
- 1978
- Deviations:
- yes
- Remarks:
- : no 72 h observation period
- Principles of method if other than guideline:
- - Principle of test: patch-test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diethyl bis(2-hydroxyethyl)aminomethylphosphonate
- EC Number:
- 220-482-8
- EC Name:
- Diethyl bis(2-hydroxyethyl)aminomethylphosphonate
- Cas Number:
- 2781-11-5
- Molecular formula:
- C9H22NO5P
- IUPAC Name:
- diethyl {[bis(2-hydroxyethyl)amino]methyl}phosphonate
- Test material form:
- liquid: viscous
- Details on test material:
- - Physical state: viscous liquid
- Colour: amber
- Expiry date: not reported
Constituent 1
- Specific details on test material used for the study:
- - Receipt date: 25 Jun 1981
- Color: amber
- Form: viscous liquid
Test animals
- Species:
- rabbit
- Strain:
- other: Stauffland albino rabbits
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Phillips Rabbitry, Soquel, USA
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL
- Duration of treatment / exposure:
- 4 h
- Observation period:
- Reading time points: 4 and 48 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 1 inch of intact skin
- Type of wrap: gauze patch held in place with adhesive tape and wrapped with rubberized damming
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 4 h
OBSERVATION TIME POINTS
- 4 and 48 h
SCORING SYSTEM:
- Method of calculation: as described by Draize (1965)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: 4/48 hr
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No indication of irritation. The observation time points differs from the 24/48/72 standard, however since there was no irritation observed at 4 or 48 hours, this deviation would probably not alter the conclusion.
- Irritant / corrosive response data:
- No adverse effects were observed for all tested animals at the time points 4 and 48 h.
- Other effects:
- - Other adverse local effects: none
- Other adverse systemic effects: none
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study, the test material is not classified according to Regulation (EC) 1272/2008 (CLP) and to the GHS.
- Executive summary:
In a primary dermal irritation study, conducted similarly to the EPA OPP 81-5 Guideline, six female Stauffland albinorabbits were dermally exposed to (0.5mL) of undiluted test material to the dorsal area of the trunk. Test sites were covered with an occlusive dressing for 4 hours. Skin reactions of the animals were assessed at removal of the patches and 48 hours after. Irritation was scored according to the Draize scale.
The test material produced no irritation in intact skin of albino rabbits.
Mean (4/48 hrs) individual erythema score: 0.00 / 0.00 / 0.00 / 0.00 / 0.00 / 0.00.
Mean (4/48 hrs) individual oedema score: 0.00 / 0.00 / 0.00 / 0.00 / 0.00 / 0.00.
Under the conditions of this study, the test material is not classified according to Regulation (EC) 1272/2008 (CLP) and to the GHS.
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