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EC number: 205-532-9 | CAS number: 142-29-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute Oral Toxicity
A range-finding toxicity study was conducted with Wistar rats using a variety of substances, including the test substance, cyclopentene. The test substance was administered to Wistar rats as a single oral LD50 dose via oral gavage. Cyclopentene was shown to have a single dose LD50 in rats of 1656 mg/kg.
Acute Inhalation Toxicity
The Kimmerle 1975 study was an investigation evaluating the acute, subacute and subchronic inhalation toxicity of the test substance, Cylopentene.After a 4 -hour exposure to about 4000 ppm or less of cyclopentene, there were no observable toxic symptoms, but those animals exposed to higher concentrations, developed an irritation of the mucosa of the upper airways. This was seen in both males and females. It can be concluded that the LC50 after a 4 -hour exposure to cyclopentene was > 22.9 mg/L air in male and female rats.
Acute Dermal Toxicity
A range-finding toxicity study was conducted with New Zealand white rabbits using a variety of substances, including the test substance, cyclopentene. After a 24 -hour exposure to cyclopentene was shown to have a single skin penetration LD50 of 1231 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions; no necropsy performed; no data about doses used; no mortality data available.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method is described in the publication of Smyth et al (cf. Reference)
Gastric intubation of groups of 5 non-fasted male Carworth-Wistar rats (age: 4-5 weeks; bw: 90-120 g). The dosages were arranged in a logarithmic series differing by a factor of two. 14 days post-exposure observation period. No further details. - GLP compliance:
- not specified
- Test type:
- other: Smyth and Carpenter (see reference)
- Limit test:
- yes
- Specific details on test material used for the study:
- Not specified
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Not specified
- Doses:
- 1656.0 mg/kg bw (Original value 2.14 ml/kg (density cyclopentene 0.774 g/ml);
As no information about the number of administered dose levels is given, the total amount of animals could not be determined. - No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Experimental methods remained unchanged and are described in the 1962 publication.
- Statistics:
- Not specified
- Preliminary study:
- Not applicable
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Remarks:
- Single oral LD50
- Effect level:
- ca. 1 656 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 4/6 rats died following a 4-hour exposure to cyclopentene at 4000 rpm (inhalation of metered vapour concentration)
- Clinical signs:
- other: Not specified
- Gross pathology:
- Not specified
- Other findings:
- Not specified
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008
- Conclusions:
- Based on the results of the study, cyclopentene had a single dose LD50 in rats of 1656 mg/kg.
- Executive summary:
A range-finding toxicity study was conducted with Wistar rats using a variety of substances, including the test substance, cyclopentene. The test substance was administered to Wistar rats as a single oral LD50 dose via oral gavage. Cyclopentene was shown to have a single dose LD50 in rats of 1656 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 656 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study with acceptable restrictions; No post-exposure observation time, no necropsy performed.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- no post-exposure observation time, no necropsy performed
- GLP compliance:
- no
- Test type:
- standard acute method
- Specific details on test material used for the study:
- Appearance: pale yellow liquid
Qualities: specific gravity=0.772/20°C, slightly water-soluble, readily soluble in alcohols, hydrocarbons and chlorinated hydrocarbons - Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Sex: male and female
- Weight at study initiation: 140-150 g
- Fasting period before study: not specified
- Housing: air-conditioned animal quarters, in groups of 5 in cages
- Diet (e.g. ad libitum): ad libitum ( Altromin standard diet)
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21°C +/-2°C
- Photoperiod (hrs dark / hrs light): 12/12 (lit from 7am-7pm daily) - Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- - Rats were exposed to vapours for 4 hours in dynamic inhalation chambers.
- During the 3-week and 12-week periods, the rats were exposed to the vapour concentrations 6 hrs/day for 5days/week. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5,8; 11,3; 16,9; 22,9 mg/l
(original dose levels: 2040, 4015, 5980 and 8110 ppm/ 4h.) - No. of animals per sex per dose:
- Each group consisted of 10 male and 10 female rats.
- Control animals:
- yes
- Remarks:
- Inhaled air only.
- Details on study design:
- 10 rats of each sex were exposed to vapours for 4 hr in dynamic inhalation chambers.
- Statistics:
- Not specified
- Preliminary study:
- Not applicable
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 22.9 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: vapour
- Remarks:
- 22.9 mg/L = 8100 ppm = 22564.05 mg/m^3
- Mortality:
- No mortalities.
- Clinical signs:
- other: After a 4-hr exposure to cyclopentene concentrations of 11,3 mg/l or less animals showed no toxic symptoms.
- Other findings:
- - The animals (males and females) exposed to higher concentrations developed symptoms which consisted of irritation of the mucosa of the upper airways
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of this study, it can be concluded that the LC50 after a 4 -hour exposure to cyclopentene was > 22.9 mg/L air in male and female rats.
- Executive summary:
This study was an investigation evaluating the acute, subacute and subchronic inhalation toxicity of the test substance, Cylopentene.
Acute toxicity:
After a 4 -hour exposure to about 4000 ppm or less of cyclopentene, there were no observable toxic symptoms, but those animals exposed to higher concentrations, developed an irritation of the mucosa of the upper airways. This was seen in both males and females.
It can be concluded that the LC50 after a 4 -hour exposure to cyclopentene was > 22.9 mg/L air in male and female rats.
Reference
Subacute inhalation toxicity
- During and after the 3 -week exposure (870 and 3100 ppm), the rats did not show any significant changes in appearance and behaviour.
- A reduced body weight gain was seen in female rats exposed to 3100 ppm.
- Autopsy revealed no signs of changes in the organs.
Subchronic inhalation toxicity
- The 1120 ppm exposure for 12 weeks caused no noticeable changes in appearance, behaviour or body weight..
- The haemotological values, serum-enzyme activities and serum concentrations of urea, creatinine, bilirubin and glucose were within the physiological range and there was no significant change in the composition of the urine.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 22 564.05 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study with acceptable restrictions; only 4 male animals per dose were used; Regarding the occlusive dressing the test protocol used was harsher; no necropsy performed
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only 4 male animals per dose were used; occlusive dressing; no necropsy performed
- Principles of method if other than guideline:
- Method is described in the publication of Smyth et al (cf. Reference)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- Not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 2.5 - 3.5 kg
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- Refer to the publication of Smyth et al (cf. Reference)
- Duration of exposure:
- 24 hours
- Doses:
- As no information about the number of administered dose levels is given, the total amount of animals could not be determined.
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- The fur is removed from the entire trunk by clipping and the dose is retained beneath an impervious plastic film.
The animals were immobilized during the contact period; 14 days post-exposure observation period. - Statistics:
- Not specified
- Preliminary study:
- Not applicable.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 231 mg/kg bw
- Mortality:
- No mortalities.
- Clinical signs:
- other: Irritation on uncovered rat belly = 5
- Gross pathology:
- Not specified
- Other findings:
- Not specified
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008
- Conclusions:
- Based on the results of the study, cyclopentene had a single skin penetration LD50 in rabbits of 1231 mg/kg bw.
- Executive summary:
A range-finding toxicity study was conducted with New Zealand white rabbits using a variety of substances, including the test substance, cyclopentene. After a 24 -hour exposure to cyclopentene was shown to have a single skin penetration LD50 of 1231 mg/kg bw.
Reference
Value of LD50 given in the literature was 1.59 ml/kg. With respect to the density of cyclopentene (0.774 g/ml), the value in mg/ml refers to 1231 mg/kg.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 231 mg/kg bw
Additional information
Justification for classification or non-classification
Based on the results, Cyclopentene is classified as Category 4 for acute oral and acute dermal toxicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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