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EC number: 218-638-5 | CAS number: 2210-25-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 November 2017 and 17 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- other: Method A.24. “Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) method”, Official Journal of the European Union L 54 of 01 March 2016
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Batch/Lot number: 2161004
Appearance: White to light yellow flakes
Purity: 99.41%
Expiry date: 31 January 2018
Storage conditions: Controlled room temperature (15-25°C, below 70 RH%), protected from light
Safety precautions: Routine safety precautions (lab coat, gloves, safety glasses, face mask) for unknown materials were applied to assure personnel health and safety. - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 0 - <= 1
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not available
- Details on results:
- The three calibration series and three test item series were measured. The partition coefficient Pow was determined based on a calibration curve using 6 reference substances.
The capacity factors k were calculated from the dead time and retention times of the reference substances. The log k data of the reference substances were plotted against their log Pow values. The equation of the curve fitted to the calibration points is as follows:
log Pow = 2.78 × log k + 1.76 (R2 = 0.952) - Conclusions:
- The estimated log Pow of NIPAM is between 0 and 1.0.
- Executive summary:
The partition coefficient (P) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system. In this case there is a partitioning between the mobile solvent phase and the hydrocarbon stationary phase. This enables the relationship between the retention time on a reverse-phase column and the
n-octanol/water partition coefficient to be established.The purpose of this study was to determine the partition coefficient of NIPAM.
The estimated log Pow of NIPAM is between 0 and 1.0.
Reference
Measured and calculated data of thereference substances
Chemical name |
log Pow |
Retention time (min) |
log k |
Repeatability |
Reproducibility |
log Pow |
OECD 117 |
Calculated |
Calculated |
||||
Thiourea |
- |
2.10 |
for determination of dead time |
|||
2.10 |
||||||
2.10 |
||||||
2.09 |
||||||
2.10 |
||||||
2.10 |
||||||
Mean |
2.10 |
|||||
CV% |
0.2 |
|||||
Acetanilide |
1.0 |
3.01 |
-0.362 |
0.04 |
0.2 |
0.8 |
3.01 |
-0.362 |
0.8 |
||||
3.02 |
-0.357 |
0.8 |
||||
3.02 |
-0.357 |
0.8 |
||||
3.03 |
-0.353 |
0.8 |
||||
3.04 |
-0.348 |
0.8 |
||||
Mean |
3.02 |
-0.357 |
0.8 |
|||
CV% |
0.4 |
- |
- |
|||
Benzonitrile |
1.6 |
4.23 |
0.007 |
0.04 |
0.2 |
1.8 |
4.23 |
0.007 |
1.8 |
||||
4.30 |
0.021 |
1.8 |
||||
4.29 |
0.019 |
1.8 |
||||
4.31 |
0.023 |
1.8 |
||||
4.31 |
0.023 |
1.8 |
||||
Mean |
4.28 |
0.017 |
1.8 |
|||
CV% |
0.9 |
- |
- |
|||
Methyl benzoate |
2.1 |
5.32 |
0.186 |
0.02 |
0.2 |
2.3 |
5.32 |
0.186 |
2.3 |
||||
5.35 |
0.190 |
2.3 |
||||
5.35 |
0.190 |
2.3 |
||||
5.38 |
0.194 |
2.3 |
||||
5.38 |
0.194 |
2.3 |
||||
Mean |
5.35 |
0.190 |
2.3 |
|||
CV% |
0.5 |
- |
- |
|||
Ethyl benzoate |
2.6 |
6.96 |
0.365 |
0.02 |
0.2 |
2.8 |
6.96 |
0.365 |
2.8 |
||||
7.01 |
0.369 |
2.8 |
||||
7.01 |
0.369 |
2.8 |
||||
7.04 |
0.372 |
2.8 |
||||
7.04 |
0.372 |
2.8 |
||||
Mean |
7.00 |
0.369 |
2.8 |
|||
CV% |
0.5 |
- |
- |
Measured and calculated data of the reference substances (continued)
Chemical name |
log Pow |
Retention time (min) |
log k |
Repeatability |
Reproducibility |
log Pow |
OECD 117 |
Calculated |
Calculated |
||||
Benzophenone |
3.2 |
8.02 |
0.451 |
0.03 |
0.2 |
3.0 |
8.02 |
0.451 |
3.0 |
||||
8.10 |
0.456 |
3.0 |
||||
8.11 |
0.457 |
3.0 |
||||
8.13 |
0.459 |
3.0 |
||||
8.15 |
0.460 |
3.0 |
||||
Mean |
8.09 |
0.456 |
3.0 |
|||
CV% |
0.7 |
- |
- |
|||
Naphthalene |
3.6 |
10.27 |
0.590 |
0.03 |
0.2 |
3.4 |
10.27 |
0.590 |
3.4 |
||||
10.36 |
0.595 |
3.4 |
||||
10.38 |
0.596 |
3.4 |
||||
10.44 |
0.599 |
3.4 |
||||
10.46 |
0.600 |
3.4 |
||||
Mean |
10.36 |
0.595 |
3.4 |
|||
CV% |
0.8 |
- |
- |
Measured and calculated data of test item
|
Retention time (min) |
log k |
log Pow |
Pow |
Calculated data |
||||
NIPAM |
2.74 |
- |
- |
- |
2.73 |
- |
- |
- |
|
2.75 |
- |
- |
- |
|
2.74 |
- |
- |
- |
|
2.74 |
- |
- |
- |
|
2.75 |
- |
- |
- |
|
Mean |
2.74 |
- |
<1.0 |
- |
Conf.(95%) |
- |
- |
- |
- |
CV% |
0.3 |
- |
- |
- |
Normally, there should beat least one reference substance havePowbelow that of the test substance.
Why did not you use areference substancewith lower Pow, such as2-Butanone?
Description of key information
The partition coefficient (P) is defined as the ratio of the equilibrium
concentrations of a dissolved substance in a two-phase system. In this
case there is a partitioning between the mobile solvent phase and the
hydrocarbon stationary phase. This enables the relationship between the
retention time on a reverse-phase column and the
n-octanol/water partition coefficient to be established.
The purpose of this study was to determine the partition coefficient ofNIPAM.
The estimated log Pow of NIPAM is between 0 and 1.0.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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