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EC number: 814-433-5 | CAS number: 926622-96-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 12,12-dimethyl-2,5,8-trioxa-11-azatridecane
- EC Number:
- 814-433-5
- Cas Number:
- 926622-96-0
- Molecular formula:
- C11 H25 N O3
- IUPAC Name:
- 12,12-dimethyl-2,5,8-trioxa-11-azatridecane
- Test material form:
- liquid
- Details on test material:
- - State of aggregation: liquid
- Purity: 99.8 corrected area-% by GC/FID For details see analytical report 17L00283.
- Storage stability: The stability of the test item under storage conditions over the study period was guaranteed by the sponsor, and the sponsor holds this responsibility.
- Storage conditions: Room temperature
- Physical state / color: Liquid / colorless, clear
- Density [g/mL]: 0.921 (determined by Bioassay Laboratories)
Constituent 1
- Specific details on test material used for the study:
- Test item No.: 17/0250-1
Batch identification: BA1948
Expiry date: May 01, 2019
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- - Nulliparous and non-pregnant female animals were used
- Acclimatization period of at least 5 days before the beginning of the experimental phase
- The animals were housed in fully air-conditioned rooms. Central air-conditioning guaranteed a range of 22°C +/- 3°C for temperature and of 30 – 70% for relative humidity. There were no deviations from these ranges, which influenced the results of the study.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- - Single oral administration by gavage.
- Feed was withdrawn from the animals at least 16 hours before administration, but water was available ad libitum. - Doses:
- 300 mg/kg and 2000 mg/kg (undiluted)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual body weights shortly before administration (day 0), weekly thereafter and sacrifice moribund on study day 3.
- Necropsy of survivors performed: yes
- Other examinations performed:
clinical signs, body weight, mortality
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- In the single 2000 mg/kg bw test group one animal died at hour 5 and one animal was sacrificed in a moribund state on study day 3. No mortality occurred in both 300 mg/kg bw test groups.
- Clinical signs:
- other: In the surviving animal of the single 2000mg/kg bw test group dyspnea and cowering position was seen from hour 1 until day 1 after administration. Poor general state was noted from hour 1 until hour 2, which regressed to impaired general state from hour 3
- Gross pathology:
- The following macroscopic pathologic findings were observed in the animal which died in the 2000 mg/kg bw test group:
o Dark discoloration of the liver
o Red discoloration of the stomach mucosa with blistering (filled with liquid) and detachment
The following macroscopic pathologic findings were observed in the animal which was sacrificed moribund in the 2000 mg/kg bw test group:
o White discoloration with black spots of the glandular stomach o White discoloration of the small intestine. There were no macroscopic pathological findings in any animal sacrificed at the end of observation period (2000 mg/kg bw: 1 female; 300 mg/kg bw: 6 females).
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of this study the median lethal dose of 2-Propanamine, N-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-2-methyl- after oral administration was found to be greater than 300 mg/kg bw and less than 2000 mg/kg bw in rats.
- Executive summary:
Under the conditions of this study the median lethal dose of 2-Propanamine, N-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]-2-methyl- after oral administration was found to be greater than 300 mg/kg bw and less than 2000 mg/kg bw in rats.
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