Registration Dossier
Registration Dossier
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EC number: 827-945-9 | CAS number: 107648-80-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In groups of volunteers, prick test and intradermal tests showed that 2.5% of subjects developed a sensitization by skin contact.
There are many studies showing the ability of penicillins and cephalosporins to cause contact allergy (contact dermatitis) .
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Many studies also show a respiratory sensitization to penicillins and cephalosporins, confirmed by appropriate tests of bronchial stimulation.A study on the intermediate most commonly used in the synthesis of cephalosporins, the 7-ACA, tends to confirm the presence of an immunological mechanism, as a result of asthma symptoms encountered in the professional field.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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