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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- not specified
- Type of method:
- other: increasing volumes of water in a glass-stoppered measuring cylinder
Test material
- Reference substance name:
- Silybum marianum extract
- Molecular formula:
- Not applicable
- IUPAC Name:
- Silybum marianum extract
- Test material form:
- liquid
- Details on test material:
- The test matérial contains 0.5% of tocophérol for stability
1
Results and discussion
Water solubility
- Key result
- Remarks on result:
- not determinable
- Details on results:
- The sample remains undissolved after addition of 10 and 100 ml of water and long time of contact (96h).
Thereafter, the experiment is continued by placing 0.1 gram of sample in 1000 ml of water. After 96h of shaking, the substance is still not dissolved (formation of small droplets of insoluble oil). This indicate that the solubility of sample is less than 0.1 g/L.
As this experimental procedure is not suitable, the solubility of each of the constituents of this UVCB substance was estimated by a calculation method based on the use of software, the Estimation Programs Interface (EPI) SuiteTM.
Any other information on results incl. tables
The calculated water solubility of individual fatty acid ethyl esters constituting the sample are summarized in the table below:
- Palmitic acid ethyl ester ( 628-97-7) : 0.00381 mg/L
- Stearic acid ethyl ester ( 111-61-5) : 0.00035 mg/L
- Oleic acid ethyl ester ( 111-62-6) : 0.00078 mg/L
- Linoleic acid ethyl ester ( 544-35-4) : 0.00171 mg/L
- Arachidic acid ethyl ester ( 18281-05-5) : 0.00003 mg/L
- Eicosenoic acid ethyl ester (ND) : 0.00007 mg/L
- Behenic acid ethyl ester ( 5908-87-2) : 0.000003 mg/L
- Myristic acid ethyl ester ( 124-06-1) : 0.04075 mg/L
- Lignoceric Acid Ethyl Ester ( 24634-95-5) : 0.0000004 mg/L
- Linoleic acid ethyl ester ( 544-35-4) : 0.0017 mg/L
The Values of water solubility calculated for the sample constituents range from 0.0000004 to 0.04075 mg/L.
Applicant's summary and conclusion
- Conclusions:
- The experimental method based on OECD Guideline 105 is not suitable and does not allow to the determination of the solubility of MILK THISTLE LIPOLAMI® ER. Nevertheless, this method has allowed to estimate that the solubility of the sample is less than 0.1 g/L.
The solubility of each constituents of this UVCB substance was estimated by a calculation method based on the use of software, the Estimation Programs Interface (EPI) SuiteTM. The Values of water solubility calculated for the sample constituents range from 0.0000004 to 0.04075 mg/L. - Executive summary:
The experimental method based on OECD Guideline 105 is not suitable and does not allow to the determination of the solubility of MILK THISTLE LIPOLAMI® ER. Nevertheless, this method has allowed to estimate that the solubility of the sample is less than 0.1 g/L.
The solubility of each constituents of this UVCB substance was estimated by a calculation method based on the use of software, the Estimation Programs Interface (EPI) SuiteTM. The Values of water solubility calculated for the sample constituents range from 0.0000004 to 0.04075 mg/L.
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