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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: Literature
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
3,3-dimethylbutanone / Oral acute exposure
Author:
Gigiena i Sanitariya
Year:
1987
Bibliographic source:
HYSAAV. Vol. 52(12), Pg. 91, 1987

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified

Test material

1
Chemical structure
Reference substance name:
3,3-dimethylbutanone
EC Number:
200-920-4
EC Name:
3,3-dimethylbutanone
Cas Number:
75-97-8
Molecular formula:
C6H12O
IUPAC Name:
3,3-dimethylbutanone
Test material form:
liquid

Test animals

Details on test animals or test system and environmental conditions:
Several animals tested : rat, rabbit and mouse

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Remarks:
rat
Effect level:
610 mg/kg bw
Sex:
not specified
Dose descriptor:
LD50
Remarks:
rabbit
Effect level:
900 mg/kg bw
Sex:
not specified
Dose descriptor:
LD50
Remarks:
mouse
Effect level:
1 625 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
Gigiena i Sanitariya presents a study on acute exposure of rats, rabbits and mice to pinacolone. This study shows the following resultas :
Oral / LD50 (rat) : 610 mg/kg
Oral / LD50 (rabbit) : 900 mg/kg
Oral / LD50 (mouse) : 1625 mg/kg
Regarding theses results, the substance is classified in the category 3 based on GHS criteria.
Executive summary:

Gigiena i Sanitariya presents a study on acute exposure of rats, rabbits and mice to pinacolone. This study shows the following resultas : Oral / LD50 (rat) : 610 mg/kg Oral / LD50 (rabbit) : 900 mg/kg Oral / LD50 (mouse) : 1625 mg/kg Regarding theses results, the substance is classified in the category 3 based on GHS criteria.