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Diss Factsheets
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EC number: 237-262-2 | CAS number: 13709-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- reproductive toxicity, other
- Remarks:
- various methods are presented in this report
- Type of information:
- experimental study
- Remarks:
- publication / peer-reviewed report
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- peer-reviewed
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Sodium Borate and Boric Acid
- Author:
- CIR
- Year:
- 1 983
- Bibliographic source:
- JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY, Volume 2, Number 7, 1983 Mary Ann Liebert, Inc., Publishers
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Review of literature data
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Boric acid
- EC Number:
- 233-139-2
- EC Name:
- Boric acid
- Cas Number:
- 10043-35-3
- Molecular formula:
- H3BO3
- IUPAC Name:
- Boric acid
- Reference substance name:
- 1303-96-4
- EC Number:
- 603-411-9
- Cas Number:
- 1303-96-4
- IUPAC Name:
- 1303-96-4
- Details on test material:
- Boric Acid (CAS No. 10043-35-3) is an inorganic acid that conforms to the formula, H3B03. It is also called boracic acid and orthoboric acid. Sodium Borate (CAS No. 1303-96-4) is an inorganic salt that conforms to the formula, Na2B4O7*10H2O. It is also called borax and sodium tetraborate. Sodium Borate occurs in pentahydrate and anhydrous forms as well as the decahydrate form. The decahydrate is the Sodium Borate that appears in the FDA product formulation computer printout and the use of the name, Sodium Borate, in the chemistry section of this report refers to the decahydrate. In references appearing in other sections of this report the specific Sodium Borate has not usually been identified.
Boric Acid occurs as colorless, odorless, transparent, triclinic crystals or white granules or powder that is slightly oily to the touch. It has a molecular weight of 61.84 and a specific gravity of 1.435. A 0.1 M solution of Boric Acid has a pH of 5.1. Boric Acid is stable in air but volatile in steam without decomposition. Its melting point is approximately 171°C when heated in a closed space. With continued heating and higher temperatures, Boric Acid loses water in stages. It becomes metaboric acid, HBO2, and then pyroboric acid, H2B4O7, followed by the oxide, B2O3. Boric Acid is soluble in hot and cold water, alcohol, and glycerin. Its solubility in water is increased by citric, hydrochloric, and tartaric acids. It is slightly soluble in acetone and not very soluble in ether.
Sodium Borate occurs colorless to white, hard, odorless, monoclinic crystals or powder. It is efflorescent in dry air and crystals are often coated with white powder. It has a molecular weight of 381.37 and a specific gravity of 1.73. An aqueous solution of Sodium Borate has a pH of approximately 9.5. When heated rapidly, Sodium Borate has a melting point of 75°C. It becomes anhydrous at 320°C. Sodium Borate is soluble in hot and cold water, and glycerin. It is very slightly soluble in alcohol and is insoluble in acid.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: various
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The present information was based on a literature review (peer-reviewed) of sodium borate and boric acid studies. Most, but not all reviewed studies indicated that boron had adverse effects on reproduction, more specific on the gonads of the males. Nevertheless, due to the limited information, obvious threshold and some deviating results, data does not suffice for classification as Repr. 1B; Repr. 2 is rather indicated.
- Executive summary:
A literature review of sodium borate and boric acid showed that these borates interfere with reproduction, mainly by effects on the gonads of the males. Data does not suffice for classification as Repr. 1B; Repr. 2 is rather indicated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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