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Diss Factsheets
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EC number: 701-266-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1963
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Intact and abraded skin of rabbits (ear and belly) were treated repeatedly with the undiluted and 10% aqueous solution of test substance. In a patch test undiluted test substance was applied for 30, 45 and 67 minutes.
- GLP compliance:
- no
Test material
- Reference substance name:
- Polyethylene polyamine, pentaethylenehexamine fraction
- EC Number:
- 701-266-7
- Molecular formula:
- Complex UVCB substance
- IUPAC Name:
- Polyethylene polyamine, pentaethylenehexamine fraction
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 30, 45 and 67 minutes
- Observation period:
- no data
- Number of animals:
- no data
Results and discussion
In vivo
Results
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- Undiluted PEHA and the 10% aqueous solution studied in the laboratory are both capable of producing severe skin injury if care is not taken to avoid confined contact or contact with abraded skin. Short contact with exposed skin areas exemplified by the ungloved hand should pose no problem. Exposures in excess of an hour, however, would likely result in considerable irritation and possibly a skin burn particularly if abrasions are present.
Any other information on results incl. tables
Skin contact rabbit - repeated application
Material |
Condition of skin |
No. of Appl. |
Site |
Response-Remarks |
Undiluted |
Intact |
5 |
Ear |
Essentially no irritation followed 1st application. Slight to moderate hyperemia thereafter. Moderate burn followed 5th. Skin healed with slight scar in 21 days. |
Undiluted |
Intact |
1 |
Belly |
Slight hyperemia and edema with extensive burn followed 1st application, Skin healed with hard black scab in 21 days. |
Undiluted |
Abraded |
1 |
Belly |
Essentially the same as above. |
10% aqueous solution |
Intact |
9 |
Ear |
Essentially no irritation observed.
|
10% aqueous solution |
Intact |
1 |
Belly |
Slight hyperemia and edema with moderate burn. Skin healed with very slight scar in 21 days. |
10% aqueous solution |
Abraded |
1 |
Belly |
Essentially the same as above with slight scar in 21 days. |
Skin Contact - Rabbit (Patch Test)
Material |
Condition of Skin |
Duration of Exposure |
Response-Remarks
|
Undiluted |
Intact |
30 minutes |
Slight hyperemia. |
Undiluted |
Intact |
45 minutes
|
No irritation observed. |
Undiluted
|
Intact |
1 hour |
Slight to moderate skin burn with slight hyperemia |
|
|
7 minutes
|
Slight scab after 5 days.
|
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Exposures in excess of an hour, however, would likely result in considerable irritation and possibly a skin burn particularly if abrasions are present.
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