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EC number: 813-358-5 | CAS number: 4886-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15.03.-09.04.16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Version / remarks:
- 2006
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-phenyl-3-(phenylsulfamoyl)urea
- EC Number:
- 813-358-5
- Cas Number:
- 4886-26-4
- Molecular formula:
- C13H13N3O3S
- IUPAC Name:
- 1-phenyl-3-(phenylsulfamoyl)urea
- Test material form:
- solid: particulate/powder
- Details on test material:
- - State of aggregation:
- Particle size distribution:
- Mass median aerodynamic diameter (MMAD):
- Geometric standard deviation (GSD):
- Shape of particles:
- Surface area of particles:
- Crystal structure:
- Coating:
- Surface properties:
- Density:
- Moisture content:
- Residual solvent:
- Activation:
- Stabilisation:
- Other:
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Common name:
- Strain:
- Source (laboratory, culture collection): Culture Collection of Algae at the University of Goettingen, Germany
- Age of inoculum (at test initiation):
- Method of cultivation:
ACCLIMATION
- Acclimation period:
- Culturing media and conditions (same as test or not):
- Any deformed or abnormal cells observed:
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 23.2 - 23.6 °C
- pH:
- 7.5 - 7.5 in the control and 7.5 - 7.7 in the test concentration
- Nominal and measured concentrations:
- nominal (limit test):174.6 mg/L
meaured (limit test): 98.5 – 101.9 % of the nominal loading rate and stable during the exposure period - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 174.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 144.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Results with reference substance (positive control):
- ErC50 of 0,831 mg/L (CI 95 %: 0,790 - 0,869 mg/L) and, therefore, is within the required range of 0.6 - 1.08 mg/L. The EyC50
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item shows a low toxicity to algae. The NOEC is calculated >= 144.9 mg/L.
- Executive summary:
Static algal growth inhibition tests with D. subspicatus were performed using maximum concentrated stock solutions (limit of solubility) with a loading rate of 200 mg/L test item. A standard test (5 test item concentrations) did not comply with all criteria of validity. As none of the test item concentrations showed inhibition of algal growth, a second test was conducted as limit test (1 test item concentration). The measured test item concentration of the stock solution at the start of the test (0 h) is used as the highest “nominal” concentration and the lower “nominal” concentrations are calculated using the corresponding concentration factors. As the measured concentrations are within ± 20 % of the “nominal” concentrations, according to OECD 201, all results are given in relation to the “nominal” test item concentrations:
Standard test
• LOEC > 144.9 mg/L test item, NOEC ≥ 144.9 mg/L test item, for yield and growth rate
The test did not comply with all three criteria of validity because the mean coefficient of variation for section-by-section specific growth rate in the control cultures was 39.3 % and, thus, higher than the limit of ≤ 35 % according to OECD 201. However, results are meaningful and relevant. The measured test item concentrations in the test treatments were 97.4 - 103.3 % of the “nominal” test item concentration and stable during the exposure period. The concentrations in the control were below the limit of quantification.
Limit test
•A statistically significant difference between control and 174.6 mg/L test item was demonstrated for yield and growth rate.
• The test is valid according to OECD Test Guideline 201 (March 2006).
The measured test item concentrations in the test treatments were 98.5 - 101.9 % of the “nominal” test item concentration and stable during the exposure period. The concentrations in the control were below the limit of quantification.
Overall results
NOEC ≥ 144.9 mg/L test item for growth rate and yield; LOEC = 174.6 mg/L test item, for growth rate and yield (corresponding to an inhibition of 6.8 % and 18.0 %, respectively)
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