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EC number: 256-296-9 | CAS number: 47107-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 (oral) > 2.000 mg/kg bw
LD50 (dermal) > 2.000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Considering the structural similarities of the substances "Iodo(triphenylphosphino)copper" and "Iodotris(triphenylphosphino)copper" and the almost identical physical and chemical properties, especially molecular weights, partition coefficients and water solubilites, it can be expected that the substances will show quite similar behaviour with respect to the toxicological endpoints acute toxicity (oral / dermal).
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 423
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 219001
- Expiration date of the lot/batch: January 01 , 2004
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: dry, room temperature, closed container - Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, D-97320 Sulzfeld
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: approximately 6 weeks
- Weight at study initiation: 214.3 g ± 6.8 g (3 .2 %)
- Fasting period before study: yes
- Housing: Makrolon® Type 3 cage
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 days before randomisation
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21,0 - 21,5
- Humidity (%): 30 - 40
- Photoperiod (hrs dark / hrs light): 12/12
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5 % tylose MH 1000 in deionized water
- Doses:
- 2.000 mg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- All animals were examined for mortality, clinical signs and body weight gain. The pathological
alterations of organs were examined at the end of a 14-day observation period. - Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Female: 2000 mg/kg bw; Number of animals: 6; Number of deaths: 0
- Clinical signs:
- No substance-related toxicological findings.
- Body weight:
- The body weight gain of the animals was not affected by the administration of the test item.
- Gross pathology:
- No substance-related pathological findings.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- None of the animals died after a single oral administration of 2000 mg/kg bw.
The LD50 (oral, rat) is> 2.000 mg/kg bw.
Clinical symptoms were not observed during the course of investigation.
The body weight gain of the animals was not affected.
No pathological findings were observed. - Executive summary:
The LD50 (oral, rat) is> 2.000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Considering the structural similarities of the substances "Iodo(triphenylphosphino)copper" and "Iodotris(triphenylphosphino)copper" and the almost identical physical and chemical properties, especially molecular weights, partition coefficients and water solubilites, it can be expected that the substances will show quite similar behaviour with respect to the toxicological endpoints acute toxicity (oral / dermal).
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 402
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 219001
- Expiration date of the lot/batch: January 01 , 2004
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: dry, room temperature, closed container - Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Species / Strain: rat/ Wistar Crl:WI BR
Rationale: The rat is a suitable rodent species for acute toxicity studies and is acceptable to regulatory authorities.
Sex: male, female (nulliparous, non-pregnant)
Supplier: Charles River Wiga GmbH, D-97320 Sulzfeld
Hygiene status upon supply: SPF
Age at start of acclimatisation: approximately 4 weeks
Acclimatisation: The animals were housed 4 weeks before administration to the housing conditions of the test facility. In this time no signs were observed which indicate an illness or other injury.
Randomisation: Animals were assigned to cages according random numbers one day prior to administration.
Mean body weight at administration:
Males: 294.0 g ± 17.7 g (6.0 %) n = 5
Females: 208.8 g ± 18.5 g (8.8 %) n = 5
Identification: Ear notches and cage labelling showing the animal number, study number, dose, sex, time of dosing and end of observation period. - Type of coverage:
- occlusive
- Vehicle:
- other: Tylose MH 1000 in deionisiertem Wasser. "ENGLISH" Tylose MH 1000 in deionized water.
- Details on dermal exposure:
- Route of administration: dermal
Preparation of animals: Approximately 24 hours before administration the fur was removed by shaving from the dorsal area (6x6 cm) of the trunk. Only animals with healthy intact skin were used.
Administration amount: 0.2 g/100 g body weight; Individual doses were adjusted according to the recorded body weight.
Form of administration: The test item was moistened with a 0.5 % (m/v) solution of Tylose MH 1000 in deionised water, applied to the shaved skin area and covered with a layer of a gaze patch and then with aluminium foil (6.5 x 6.5 cm). This patch was held in contact with the skin by occlusive dressing (Elastoplast, Beiersdorf AG).
Time of administration: single administration on May 06, 2003, 7.08 - 7.38 a.m.
Exposure period: After 24 hours the patch was removed and the application area was cleaned with deionised water without altering the integrity of the epidermis. - Duration of exposure:
- 24 h
- Doses:
- 2.000 mg/kg bw
- No. of animals per sex per dose:
- 10 (5 males / 5 females)
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- None of the animals showed alterations of the general state of well-being during the course of investigation.
- Body weight:
- The body weight gain of the animals was not affected by the administration of the test item.
- Gross pathology:
- There were no macroscopic pathological findings in the animals.
- Other findings:
- No substance-related local effects.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 (dermal, rat) is > 2.000 mg/kg bw.
- Executive summary:
Acute dermal toxicity of the substance was tested in 5 male and 5 female Charles River Wistar rats. The test item was applied at a single dose of 2000 mg/kg body weight to a shaved dorsal area of the trunk of the animals and was then covered with a gauze patch which was held in contact with the skin with an occlusive dressing. Exposure was for 24 hours.
Animals were examined for mortality, clinical signs, alterations of the administration area, body
weight gain and pathological alterations of organs at the end of a 14-day observation period.
None of the animals died during the course of the investigation.
The LD50 (dermal, rat) is > 2.000 mg/kg bw.
Clinical signs were not observed during the observation period.
The body weight gain of the animals was not affected by the test item.
No pathological findings were observed at necropsy.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
Considering results of the structural similar compound Iodotris(triphenylphosphino)copper,
Iodo(triphenylphosphino)copper has not to be classified as "acute toxic" for the exposure routes "oral" and "dermal", since the classification criteria according to (EU) No. 1272/2008 are not fulfilled.
A study on acute oral toxicity with Iodo(triphenylphosphino)copper itself - though not conducted according to GLP conditions - indicates an LD50 above 6000 mg/kg bw and supports the results mentioned above.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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