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EC number: 608-408-6 | CAS number: 29736-24-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 18, 2009 - June 10, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in compliance with: "Chemikaliengesetz", dated July 25, 1994 and "OECD Principles of Good Laboratory Practice", as revised in 1997
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- none
Test animals / tissue source
- Species:
- other: Lohmann selected Leghorn chicken eggs
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other: Eggs treated with each 300 μL physiological NaCl solution (0.9% (v/v)) without other substanc es) were used as negative controls. 3 eggs were tested.
- Duration of treatment / exposure:
- The eggs were obtained from the LSL Rhein-Main Geflügelvermehrungsbetriebe (D-64807 Dieburg,
Germany) on day one. Afterwards they were incubated at 37,5 ± 0.5 °C for eight days. While incuba
tion the eggs were rotated to prevent an attachment of the embryo to one side of the egg. On day ei
ght the eggs were candled and non-viable eggs were discarded. The rest of the eggs were placed
upward in the incubator and were incubated for another day without rotation. - Observation period (in vivo):
- The observation time was 300 s at room temperature.
- Number of animals or in vitro replicates:
- 6 eggs
Results and discussion
In vitro
Results
- Irritation parameter:
- other: Mean irritancy index
- Run / experiment:
- 1 to 6
- Value:
- 0.66
- Remarks on result:
- no indication of irritation
- Remarks:
- Values <0.9 are related to the outcome "non irritant"
Any other information on results incl. tables
The solid test item was tested non dissolved. Therefore each about 100 mg of the test item was applied to the membrane so that at least 50% of the membrane was covered by the test item. During the observation for 300 seconds lesions in close proximity to the covered membrane were noted.
Physiological sodium chloride solution was used as negative control.The negative control showed no irritating effect on the blood vessels under the membrane.An 1% solution of SDS and 0.1 N solution of NaOH were used as positive controls.
The positive controls induced a severe irritation on the blood vessels. The calculated mean irritancy indices are 10.11 for 1% SDS and 18.85 for 0.1 N NaOH.
No irritating effects were observed during 5 min incubation with the test item. The calculated irritancy mean index is 0.66.
Test Group |
Time until Haemorrhage [s] |
Time until Lysis [s] |
Time until Coagulation [s] |
Irritancy Index |
Mean Irritancy Index |
Negative Control |
301 |
301 |
301 |
0.00 |
0.00 |
Negative Control |
301 |
301 |
301 |
0.00 |
|
Negative Control |
301 |
301 |
301 |
0.00 |
|
Positive Control 0.1 N NaOH |
11 |
66 |
11 |
19.02 |
18.85 |
Positive Control 0.1 |
8 |
79 |
13 |
18.70 |
|
Positive Control 0.1 |
8 |
75 |
12 |
18.83 |
|
Positive Control 1% SDS |
18 |
63 |
301 |
10.27 |
10.11 |
Positive Control 1% SDS |
23 |
73 |
301 |
9.95 |
|
Positive Control 1% SDS |
20 |
69 |
301 |
10.10 |
|
Test Item |
301 |
301 |
301 |
0,00 |
0.66 |
Test Item |
301 |
301 |
301 |
0,00 |
|
Test Item |
301 |
301 |
301 |
0,00 |
|
Test Item |
301 |
301 |
301 |
0,00 |
|
Test Item |
180 |
301 |
301 |
2,02 |
|
Test Item |
185 |
301 |
301 |
1,93 |
CAMMean Irritancy Index |
Evaluation |
0 – 0.9 |
Non irritant |
1 – 4.9 |
Slight irritant |
5 – 8.9 |
Moderate irritant |
9 - 21 |
Severe irritant |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item does not possess an irritating potential.
- Executive summary:
The test did not reveal any irritant properties. Thus it is evident, that disodium hydroxy(sulfinato)acetate
is devoid of adverse reactivity towards mucous membranes.
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