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EC number: 941-183-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
[Please provide information for all of the points below. Indicate if further information is included as attachment to the same record, or elsewhere in the dataset (insert links in 'Cross-reference' table)]
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
[Describe why the read-across can be performed (e.g. common functional group(s), common precursor(s)/breakdown product(s) or common mechanism(s) of action]
The read-across target substance EP-49-10P2 is composed of a mixture of phosphate esters with bisphenol A diglycidylether (BADGE, CAS 1675-54-3, EC 216-823-5) that is dissolved in BADGE. The amount of esters in the target substance EP-49-10P2 ranges between 10% and 20%; the large rest is BADGE. Therefore, BADGE can be used as read-across source substance.
Based on the high content of BADGE (80-90%) and on the fact that the phosphate esters have higher molecular weights (MW > 1200 Da – approx. 3500 Da) and accordingly lower bioavailability it is concluded that the toxic and eco-toxic potential of EP-49-10P2 will be the same as that of BADGE. With the phosphate esters no hazardous functional groups are introduced.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
[Provide here, if relevant, additional information to that included in the Test material section of the source and target records]
3. ANALOGUE APPROACH JUSTIFICATION
[Summarise here based on available experimental data how these results verify that the read-across is justified]
No experimental data from toxicological or eco-toxicological studies with the target substance EP-49-10P2 are available for comparison of effects. However, based on the composition of EP-49-10P2 it is considered justified to make read-across from study results obtained with the read-across source substance BADGE in order to fulfil the information requirements for REACH registration of EP-49-10P2. - Reason / purpose for cross-reference:
- read-across source
- Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 116 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: extrapolated based on Arrhenius equation
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 86 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: extrapolated based on Arrhenius equation
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 171 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: extrapolated based on Arrhenius equation
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Remarks:
- Not specified in report
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Test Method A6
- Deviations:
- yes
- Remarks:
- 24 hours was used to reach equilibrium
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- pH 4: Citric acid
pH 7: disodium tetraborate
pH 9: disodium tetraborate
pH 11: disodium tetraborate - Details on test conditions:
- Test solutions of 100 ml at 1.93 mg/l test material were perpared by adding the appropriate amount of stock solution (1 ml) in acetonitrile to the preheated buffer solution (50°C). Solutions were shaken and placed in a thermostatic water bath in the dark.
a preliminary test and two definitve tests were performed with the following sampling times (hours):
preliminary: 0,3 ,6, 24
Test I: 0, 1.5, 3, 4.5, 6, 7.5
Test II: 0, 2, 4, 21, 23.5
Completely hydrolysed solution was prepared in order to verify that hydrolysis products do not co-elute with the parent material. Solutions were prepared in pH 11 buffer and incubated at 50°C for 24 hrs. - Duration:
- 0 h
- pH:
- 4
- Temp.:
- 50
- Initial conc. measured:
- 1.377 mg/L
- Duration:
- 0 h
- pH:
- 7
- Temp.:
- 50
- Initial conc. measured:
- 1.274 mg/L
- Duration:
- 0 h
- pH:
- 9
- Temp.:
- 50
- Initial conc. measured:
- 1.311 mg/L
- Duration:
- 0 h
- pH:
- 4
- Temp.:
- 38
- Initial conc. measured:
- 1.193 mg/L
- Duration:
- 0 h
- pH:
- 7
- Temp.:
- 38
- Initial conc. measured:
- 1.194 mg/L
- Duration:
- 0 h
- pH:
- 9
- Temp.:
- 38
- Initial conc. measured:
- 1.153
- Number of replicates:
- 1 per Test and pH value
- Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 116 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: extrapolated based on Arrhenius equation
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.01 h-1
- DT50:
- 86 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: extrapolated based on Arrhenius equation
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 171 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: extrapolated based on Arrhenius equation
- Conclusions:
- The rates of hydrolysis measured allowed the calculation of the half-life at 25°C:
pH 4 : 116 hours
pH 7 : 86 hours
pH 9 : 171 hours
Within the limits of the exptrapolation, these results are typical of epoxy containing compounds. - Executive summary:
The rate of hydrolysis of EPIKOTE 828 has been measured at the three pH values (4, 7, 9) and two temperatures (38°C, 50°C). Analysis of the content of the main component was performed by high performance liquid chromatography, using direct injection of the aqueous samples. All the tests showed a decline in the concentration of the test substance according to first-order kinetics.
The extrapolated half lives at pH 4, 7 and 9 were typical of epoxy compounds. Regression of the six data points, expressed as log (half life) and reciprocal temperature, gave an overall half life of 117 hours at 25°C, assuming the rate to be independent of pH, which is known to be a reasonable assumption.
Referenceopen allclose all
Preliminary test | ||||||
pH | Temperature | Tiime | conc. [mg/l] | ln(conc.) | ||
4 | 50 | 0 | 1.127 | 0.120 | ||
4 | 50 | 3 | 0.951 | -0.050 | ||
4 | 50 | 6 | 0.665 | -0.408 | ||
4 | 50 | 24 | 0.176 | -1.737 | ||
7 | 50 | 0 | 1.184 | 0.169 | ||
7 | 50 | 3 | 0.907 | -0.098 | ||
7 | 50 | 6 | 0.665 | -0.408 | ||
7 | 50 | 24 | 0.203 | -1.595 | ||
9 | 50 | 0 | 1.112 | 0.106 | ||
9 | 50 | 3 | 0.957 | -0.044 | ||
9 | 50 | 6 | 0.772 | -0.259 | ||
9 | 50 | 24 | 0.242 | -1.419 | ||
Kinetic analysis | ||||||
pH=4 | pH=7 | pH=9 | ||||
Intercept | 0.124 | 0.0077 | 0.126 | |||
gradient | -0.078 | -0.061 | -0.064 | |||
standard error of gradient | 0.003 | 0.006 | 0.001 | |||
half-life [hr] | 8.9 | 11.3 | 10.8 | |||
r^2 | 0.996 | 0.979 | 0.999 | |||
Test II: | ||||||
pH | Temperature | Tiime | conc. [mg/l] | ln(conc.) | ||
4 | 50 | 0 | 1.377 | 0.320 | ||
4 | 50 | 1.5 | 1.188 | 0.172 | ||
4 | 50 | 3 | 1.008 | 0.008 | ||
4 | 50 | 4.5 | 0.898 | -0.108 | ||
4 | 50 | 6 | 0.741 | -0.300 | ||
4 | 50 | 7.5 | 0.665 | -0.408 | ||
7 | 50 | 0 | 1.274 | 0.242 | ||
7 | 50 | 1.5 | 1.131 | 0.123 | ||
7 | 50 | 3 | 0.972 | -0.028 | ||
7 | 50 | 4.5 | 0.898 | -0.108 | ||
7 | 50 | 6 | 0.754 | -0.282 | ||
7 | 50 | 7.5 | 0.735 | -0.308 | ||
9 | 50 | 0 | 1.1311 | 0.123 | ||
9 | 50 | 1.5 | 1.185 | 0.170 | ||
9 | 50 | 3 | 0.923 | -0.080 | ||
9 | 50 | 4.5 | 0.875 | -0.134 | ||
9 | 50 | 6 | 0.779 | -0.250 | ||
9 | 50 | 7.5 | 0.722 | -0.326 | ||
Kinetic analysis | ||||||
pH=4 | pH=7 | pH=9 | ||||
Intercept | 0.317 | 0.229 | 0.249 | |||
gradient | -0.099 | -0.077 | -0.082 | |||
standard error of gradient | 0.003 | 0.006 | 0.008 | |||
half-life [hr] | 7 | 9 | 8.5 | |||
r^2 | 0.996 | 0.978 | 0.959 | |||
Test II | ||||||
pH | Temperature | Tiime | conc. [mg/l] | ln(conc.) | ||
4 | 36 | 0 | 1.193 | 0.176 | ||
4 | 36 | 2 | 1.082 | 0.079 | ||
4 | 36 | 4 | 1.015 | 0.015 | ||
4 | 36 | 21 | 0.669 | -0.402 | ||
4 | 36 | 23.5 | 0.604 | -0.504 | ||
7 | 36 | 0 | 1.194 | 0.177 | ||
7 | 36 | 2 | 1.067 | 0.065 | ||
7 | 36 | 4 | 1.026 | 0.026 | ||
7 | 36 | 21 | 0.65 | -0.431 | ||
7 | 36 | 23.5 | 0.616 | -0.485 | ||
9 | 36 | 0 | 1.153 | 0.142 | ||
9 | 36 | 2 | 1.111 | 0.105 | ||
9 | 36 | 4 | 1.057 | 0.055 | ||
9 | 36 | 21 | 0.729 | -0.316 | ||
9 | 36 | 23.5 | 0.712 | -0.340 | ||
Kinetic analysis | ||||||
pH=4 | pH=7 | pH=9 | ||||
Intercept | 0.147 | 0.143 | 0.141 | |||
gradient | -0.0272 | -0.0265 | -0.0205 | |||
standard error of gradient | 0.0012 | 0.0013 | 0.0009 | |||
half-life [hr] | 25.6 | 26.2 | 33.8 | |||
r^2 | 0.994 | 0.993 | 0.995 | |||
Description of key information
half-life 117 h at 25°C (OECD 111)
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 117 h
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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