Registration Dossier
Registration Dossier
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EC number: 947-344-6 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Remarks:
- Ethylhexyl Laurate
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- - Principle of test:
Ames test
- Short description of test conditions: Ethylhexyl Laurate is tested at doses 8, 40, 200, 1000 and 5000 microg/plate - GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-ethylhexyl laurate
- EC Number:
- 243-697-9
- EC Name:
- 2-ethylhexyl laurate
- Cas Number:
- 20292-08-4
- Molecular formula:
- C20H40O2
- IUPAC Name:
- 2-ethylhexyl laurate
- Test material form:
- liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: not specified
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
Results and discussion
Test results
- Key result
- Species / strain:
- S. typhimurium, other: not specified
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Ethylhexyl Laurate is not mutagenic in an Ames test performed in S. typhimurium (strains not specified) with and without metabolic activation.
Tridecyl Stearate and TRidecyl Palmitate with longer Carbon chain can be assumed to be non genotoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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