Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-090-8 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- other: Assessment based on experimental data on individual constituents of the substance
- Adequacy of study:
- key study
- Study period:
- June 06, 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment based on experimental data on individual constituents of the substance
Data source
Reference
- Reference Type:
- other: Expert assessment
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Assessment based on experimental data on individual constituents of the substance
- GLP compliance:
- no
- Type of study:
- other: Assessment based on experimental data on individual constituents of the substance
Test material
- Reference substance name:
- morpholin-4-ium morpholine 6-(4-methylbenzenesulfonamido)hexanoate
- EC Number:
- 944-090-8
- Molecular formula:
- C13H19NO4S.C4H9NO/C4H9NO/H2O
- IUPAC Name:
- morpholin-4-ium morpholine 6-(4-methylbenzenesulfonamido)hexanoate
- Test material form:
- liquid
Constituent 1
Results and discussion
In vivo (LLNA)
Results
- Key result
- Parameter:
- other: skin sensitisation
- Remarks on result:
- other: Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An assessment of the capacity of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) was performed based on experimental data on individual constituents of the substance. It is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce skin sensitisation.
- Executive summary:
The potential of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) to induce skin sensitisation is expected to be driven by the capacity of its constituents – 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid, morpholine, and water – to induce skin sensitisation.
A GLP-compliant skin sensitisation study has been performed on 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid that concluded that the substance is not a skin sensitiser.
Available literature data on morpholine indicated that the substance was not a skin sensitiser.
As a substance included in Annex IV of REACH, water is not considered as a skin sensitiser.
Based on the activity of its constituents, it is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce skin sensitisation. No further testing is considered as required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
