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Diss Factsheets
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EC number: 201-762-9 | CAS number: 87-66-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: ANFOR T90-303 Juin 1978
- Version / remarks:
- Essais des eaux. Détermination de la toxicité aigüe d'une substance vis à vis de Brachydanio Rerio (essai statique).
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 7346-1 (Determination of the Acute Lethal Toxicity of Substances to a Freshwater Fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)] - Part 1: Static Method)
- Deviations:
- no
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: not specified
- Expiration date of the lot/batch: not specified
- Purity test date: not specified
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: not applicable
- Specific activity: not applicable
- Locations of the label: not applicable
- Expiration date of radiochemical substance: not applicable
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not specified
- Stability under test conditions: not specified
- Solubility and stability of the test substance in the solvent/vehicle: not specified
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not specified
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: according to the reported guideline
- Preliminary purification step (if any): -
- Final dilution of a dissolved solid, stock liquid or gel: -
- Final preparation of a solid: -
FORM AS APPLIED IN THE TEST (if different from that of starting material) -
TYPE OF BIOCIDE/PESTICIDE FORMULATION (if applicable) -
OTHER SPECIFICS: - - Analytical monitoring:
- not specified
- Details on sampling:
- according to the reported guideline
- Vehicle:
- not specified
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Strain: Hamilton Buchanan
- Source: not specified
- Age at study initiation (mean and range, SD): not specified
- Length at study initiation (length definition, mean, range and SD): 2.5 ± 0.2 cm (without the tail)
- Weight at study initiation (mean and range, SD): not specified
- Method of breeding: not specified
- Maintenance of the brood fish: Fishes are bought at maturity and then raised in the laboratory in an aquarium with a capacity of 100 liters containing 70 liters of "aged" water.
ACCLIMATION
- Acclimation period: The acclimation period lasts as a minimum two weeks before use for the tests
- Acclimation conditions (same as test or not): not specified
- Type and amount of food during acclimation: not specified
- Feeding frequency during acclimation: not specified
- Health during acclimation (any mortality observed): not specified
QUARANTINE (wild caught)
- Duration: not specified
- Health/mortality: not specified
FEEDING DURING TEST
- Food type: TETRAMIN (commercial food).
- Amount: not specified
- Frequency: the fish are fed daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Remarks on exposure duration:
- At different reading times, mortalities are recorded.
- Hardness:
- 150 mg/L CaCO3
- Test temperature:
- 22 deg C
- pH:
- pH 7.8-8
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Conductivity:
- no data
- Nominal and measured concentrations:
- Concentration:
35000-100000 ug/L for 2 and 4 hours
10000-35000 ug/L for 6 and 24 hours - Details on test conditions:
- TEST SYSTEM
- Test vessel: The aquariums are covered with a glass plate during the tests
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: aquariums with a capacity of 7 liters
- Aeration: no aeration is practiced
- Type of flow-through (e.g. peristaltic or proportional diluter): not specified
- Renewal rate of test solution (frequency/flow rate): not specified
- No. of organisms per vessel: Five fishes were used for each concentration.
- No. of vessels per concentration (replicates): not specified
- No. of vessels per control (replicates): not specified
- No. of vessels per vehicle control (replicates): not specified
- Biomass loading rate: not specified
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Fish toxicity tests are carried out in aquariums with a capacity of 7 liters containing 2 liters of test solution. - Total organic carbon: not specified
- Particulate matter: not specified
- Metals: not specified
- Pesticides: not specified
- Chlorine: not specified
- Alkalinity: not specified
- Ca/mg ratio: not specified
- Culture medium different from test medium: not specified
- Intervals of water quality measurement: not specified
OTHER TEST CONDITIONS
- Adjustment of pH: not specified
- Photoperiod: not specified
- Light intensity: the fihes were placed in controlled room under a natural lighting.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not specified
- Justification for using less concentrations than requested by guideline: not specified
- Range finding study not specified
- Test concentrations: < 1 mg/I, 1-3,5; 3,5-10; 10-35; 35-100 and >= 100 mg/l
- Results used to determine the conditions for the definitive study: AFNOR T 90-303 (1978) - Reference substance (positive control):
- yes
- Duration:
- 2 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 35 000 - < 100 000 µg/L
- Nominal / measured:
- not specified
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 4 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 000 - < 35 000 µg/L
- Nominal / measured:
- not specified
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 6 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 000 - < 35 000 µg/L
- Nominal / measured:
- not specified
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 000 - < 35 000 µg/L
- Nominal / measured:
- not specified
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC 50 (24h) was in the range 10-35 mg/l for Brachydanio reri, at test described test conditions.
Considering the results, accoring to CLP classification critiria, the substance was judged as hazardous to the aquatic environment: the substance has an harmonized classification as Aquatic Chronic 3 H412 - Executive summary:
The acute toxicity of analytical grade of Pyrogallol has been tested on Brachydanio rerio after different periods of contact: 2, 4, 6 and 24 hours. The LC50 were determined.
Reference
Description of key information
The acute toxicity of Pyrogallol was tested on Brachydanio rerio and observed at 2, 4, 6 and 24 hours, according to ISO/DIS 7346/1; the preliminary test was performed according to AFNOR T 90-303 (1978).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 10 mg/L
Additional information
The LC 50 (24h) was in the range 10-35 mg/l for Brachydanio rerio, at test described test conditions.
According to the results, the substance was considered as hazardous for aquatic environment and classified as Aquatic chronic 3 H412.
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