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EC number: 200-309-2 | CAS number: 57-06-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity studies with AITC have been performed by oral, dermal and inhalation routes of exposure.
The acute LD50 of AITC by oral route is estimated to be 425.4 mg/kg bw in rats.
The acute LD50 of AITC by dermal route was between 200 and 2,000 mg/kg bw in rats.
The acute LC50 of AITC by inhalation route was between 0.206 and 0.508 mg/L/4h in rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Route of administration:
- oral: gavage
- Doses:
- 175, 55, 175, 550, 2000, 550, 2000, 550 mg/kg bw
- No. of animals per sex per dose:
- 8
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 425.4 mg/kg bw
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of this study, the acute LD50 of IR9804 is estimated to be 425.4 mg/kg bw (based on maximum likelihood and an assumed sigma of 0.5) in female rats with a 95% PL (Profile-Likelihood based confidence interval) Confidence interval of 0 mg/kg (lower) to greater than 20,000 mg/kg (upper).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 425.4 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- yes
- Test type:
- fixed concentration procedure
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- not specified
- Mass median aerodynamic diameter (MMAD):
- >= 1.67 - <= 3.21 µm
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0.05, 0.5 mg/L
- No. of animals per sex per dose:
- 10 (5 males and 5 female)
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.206 - < 0.508 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- An acute inhalation toxicity test was conducted with rats to determine the potential for IR9804 to produce toxicity from a single exposure via the inhalation (nose-only exposure) route. Under the conditions of this study, the 4-hour exposure acute inhalation LC50 of the test substance (calculated as a Time Weighted Average) appears to be between 0.206 and 0.508 mg/L in male and females rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 206 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The appropriate amount of test substance (200 or 2,000 mg/kg bw) was applied evenly over a dose area of approximately 10% of the body surface and covered with a gauze pad. After 24h of exposure to the substance, the pads were removed and the test sites were gently cleansed of any residual test substance.
- Duration of exposure:
- 24h
- Doses:
- 200 or 2,000 mg/kg bw
- No. of animals per sex per dose:
- 10 (5 males and 5 females)
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200 mg/kg bw: 0/10
2,000 mg/kg bw: 9/10 - Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- An acute dermal toxicity test was conducted with rats to determine the potential for IR9804 to produce toxicity from a single topical application. Under test conditions of this study, the single dose acute dermal LD50 of the test substance is between 200 and 2,000 mg/kg bw of body weight in male and female rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 200 mg/kg bw
Additional information
Justification for classification or non-classification
According to the available data, AITC is classified as:
Acute Tox. 4, H302
Acute Tox. 3, H311
Acute Tox 2, H330
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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