Reaction products of 2-hydroxyethyl methacrylate and diphosphorous pentoxide and water

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20-02-2018 to 26-07-2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Guideline study performed under GLP. All relevant validity criteria were met with acceptable deviations that yield scientifically plausible results.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: isothermal thermogravimetry

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

<= 7.6 Pa

Remarks on result:

other: weight losses of the test item were compared with the results of naphthalene at 50°C and 60°C

Test no.:

#2

Temp.:

25 °C

Vapour pressure:

<= 12 Pa

Remarks on result:

other: weight losses of the test item were compared with the results of naphthalene at 50°C and 60°C

The results of the isothermal TGA analysis for the test item and the vapour pressure at 20°C and 25°C are given below:

Table 1: Results of the isothermal TGA analysis

Temperature [°C]	Weight loss [µg/min]
50	7.86543
60	2.78110
70	6.15794
80	12.8712

 

In the range of 50°C and 80°C a log p versus 1/T curve for the test item could not be determined since the coefficient of correlation (r) was < 0.99 (reported in the full study report). 

Since no accurate vapour pressure could be calculated from the obtained results the weight losses of the test item were compared with the results of naphthalene at 50°C and 60°C. According to this the vapour pressure of the test item was determined to be lower than that of naphthalene

 

Table 2: Vapour pressure of the test item

	20°C		25°C
	[Pa]	[mm Hg]	[Pa]	[mm Hg]
Test item	< 7.6	< 5.7´10-2	< 12	< 8.6´10-2

 

Applicant assessment indicates: Reported literature values for naphthalene indicate: Vapour Pressure = 7.2 Pa at 20 °C and 10.5 Pa at 25 °C. Reference: DeKruif C.G. et al., (1982): J. Chem. Thermodynamics 13, 1081-1086

Conclusions:

The vapour pressure of the test item was determined to be < 7.6 Pa at 20°C (293K) and < 12 Pa at 25°C (298K), respectively.

Executive summary:

The vapour pressure was determined using the thermogravimetric effusion method in OECD TG 104, EU Method A.4 and US EPA OPPTS 830.7950 under GLP. The vapour pressure of the test item was determined to be: < 7.6 Pa (5.7 x10^-2 mmHg) at 20°C (293K) and < 12 Pa (8.6 x10^-2 mmHg) at 25°C (298K), respectively.

Applicant assessment indicates: Reported literature values for naphthalene indicate: Vapour Pressure = 7.2 Pa at 20 °C and 10.5 Pa at 25 °C. Reference: DeKruif C.G. et al., (1982): J. Chem. Thermodynamics 13, 1081-1086. Published literature values for 2-hydroxyethyl methacrylate, (ECHA, 2018) indicate a range of Vapour Pressures of 8.0 Pa at 20 °C and 13 Pa at 25 °C. For the test item the quoted ranges of vapour pressure are scientifically plausible limit values. Comparable with a measured reference substance (naphthalene) and information concerning residual starting material (2-hydroxyethyl methacrylate).

Description of key information

Vapour Pressure: < 7.6 Pa at 20 °C and < 12 Pa at 25 °C, OECD TG 104 - thermogravimetric effusion method, 2018

Key value for chemical safety assessment

Vapour pressure:

12 Pa

at the temperature of:

25 °C

Additional information

Key study : OECD TG 104, 2018 : The vapour pressure was determined using the thermogravimetric effusion method in OECD TG 104, EU Method A.4 and US EPA OPPTS 830.7950 under GLP. The vapour pressure of the test item was determined to be: < 7.6 Pa (5.7 x10^-2 mmHg) at 20°C (293K) and < 12 Pa (8.6 x10^-2 mmHg) at 25°C (298K), respectively.

Applicant assessment indicates: Reported literature values for naphthalene indicate: Vapour Pressure = 7.2 Pa at 20 °C and 10.5 Pa at 25 °C. Reference: DeKruif C.G. et al., (1982): J. Chem. Thermodynamics 13, 1081-1086. Published literature values for 2-hydroxyethyl methacrylate, (ECHA, 2018) indicate a range of Vapour Pressures of 8.0 Pa at 20 °C and 13 Pa at 25 °C. For the test item the quoted ranges of vapour pressure are scientifically plausible limit values. Comparable with a measured reference substance (naphthalene) and information concerning residual starting material (2-hydroxyethyl methacrylate).