Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 292-772-2 | CAS number: 90990-11-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Studies conducted pre-GLP standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Regulations for the Enforcement of the Federal Hazardous Substances Act. F.R. Sept. 17, 1964
- GLP compliance:
- no
Test material
- Reference substance name:
- Stearic acid
- EC Number:
- 200-313-4
- EC Name:
- Stearic acid
- Cas Number:
- 57-11-4
- Molecular formula:
- C18H36O2
- IUPAC Name:
- stearic acid
- Details on test material:
- - Analytical purity: no data
- Physical state: white solid - melted and allowed to cool before application
- Batch no.: 1922-67
- Carbon chain length distribution: C18.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Vehicle:
- not specified
- Controls:
- other: the untreated left eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Observation period (in vivo):
- Reading time points: 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: not applicable
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- out of all 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- No Lesions were observed after application of 0.1 mL test substance in rabbits eyes.
Any other information on results incl. tables
Scores for Ocular Lesions
Rabbit No. |
24 hrs. |
48 hrs. |
72 hrs. |
|
13 |
Cornea opacity, degree Cornea opacity, area Iris Conjunctiva Redness Chemosis Discharge |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
14 |
Cornea opacity, degree Cornea opacity, area Iris Conjunctiva Redness Chemosis Discharge |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
15 |
Cornea opacity, degree Cornea opacity, area Iris Conjunctiva Redness Chemosis Discharge |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
16 |
Cornea opacity, degree Cornea opacity, area Iris Conjunctiva Redness Chemosis Discharge |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
17 |
Cornea opacity, degree Cornea opacity, area Iris Conjunctiva Redness Chemosis Discharge |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
18 |
Cornea opacity, degree Cornea opacity, area Iris Conjunctiva Redness Chemosis Discharge |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
0 0 0 0 0 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DSD: not classified
CLP: not classified
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