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EC number: 215-355-9 | CAS number: 1323-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 February to 12 February 2018
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- 2006 (Annex 5 Correction July 28, 2011)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- A sample of the test substance, Glyceryl Monohydroxystearate (Synonyms: GMHS, Naturechem GMHS), an off-white solid was received from EAG Laboratories (formerly Wildlife International), Easton, Maryland on 29 November 2017 and was stored at room temperature.
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- The parent stock of Pseudokirchneriella subcapitata, formerly known as Selenastrum capricornutum, was obtained from the Department of Botany, Culture Collection of Algae, University of Texas at Austin, on 18 July 2017. The prepared cultures were maintained in a temperature-controlled environmental chamber under continuous light.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Test temperature:
- 23.5°C to 25.0°C
- pH:
- 7.3 to 7.5
- Nominal and measured concentrations:
- The substance was tested at five nominal concentration levels of 6.3 mg/L, 13 mg/L, 25 mg/L, 50mg/L, and 100 mg/L.
- Details on test conditions:
- Following preliminary range-finding tests, a definitive test was conducted exposing the unicellular green alga, Pseudokirchneriella subcapitata to aqueous WAF solutions of the test item at nominal concentrations of 6.3 mg/L, 13 mg/L, 25 mg/L, 50 mg/L and 100 mg/L for 72 hours at a temperature of 23.5 to 25.0°C. The primary objective of the test was to define the concentration response curve and estimate 72 hour EC50 values for GMHS. The EC50 estimates were based on growth rate (i.e., ErC50) and yield (i.e., EyC50).
- Reference substance (positive control):
- no
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- yes
- Remarks:
- Algal cells in control at 72 h > 16 times original; mean coef. of var. daily growth rates in control reps not > 35%; coeff.of var. of avg sp.growth rates in control reps did not exceed 7%.; pH in the control did not increase more than 1.5.
- Conclusions:
- The test substance did not cause a reduction of growth in a series of algal cultures (test units) exposed to the test item for 72 h. The 72 h NOEC and the 72 h EC50 was 100 mg/L or greater as determined by comparison of areas in growth curves. The 24 h to 48 h NOEC EC50 was 100 mg/L or greater as determined by comparison of growth rates.
Reference
Description of key information
The key study was a static acute toxicity test on the effects of the substance on the freshwater unicellular green alga, Pseudokirchneriella subcapitata following OECD Guideline 201. The test substance did not cause a reduction of growth in a series of algal cultures (test units) exposed to the test item for 72 h. The 72 h NOEC and the 72 h EC50 were 100 mg/L or greater as determined by comparison of areas in growth curves. The 24-h to 48 h NOEC EC50 was 100 mg/L or greater as determined by comparison of growth rates.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.