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Diss Factsheets
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EC number: 205-760-9 | CAS number: 150-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-05-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD TG 425, OPPTS 870.1100 and in accordance with the Principles of Good Laboratory Practice (GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Trimethyl borate
- EC Number:
- 204-468-9
- EC Name:
- Trimethyl borate
- Cas Number:
- 121-43-7
- Molecular formula:
- C3H9BO3
- IUPAC Name:
- trimethyl borate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Name of test material (as cited in study report): Trimethyl borate- Physical state: clear liquid with an alcohol odor- Composition of test material, percentage of components: > 99%- Lot/batch No.: Lot #42Y4A09T, TD#04-001 further identified with PSL Reference Number 040210-3R- Stability under test conditions: Test substance was expected to be stable for the duration of testing.- Storage condition of test material: stored in a tightly closed container, at room temperature
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Received from Ace Animals, Inc., Boyertown, PA- Age at study initiation: 11-12 weeks- Weight at study initiation: 221-247 grams at experimental start- Fasting period before study: yes- Housing: The animals were singly housed in suspended stainless steel caging with mesh floors which conformed to the size recommendations in the Guide for the Care and Use ofLaboratoiy Animals DHEW (NIH). Litter paper was placed beneath the cage and was changed at least three times per week.- Diet (e.g. ad libitum): Purina Rodent Chow #5012 was supplied ad-libitum (except during pre-dose fasting)- Water (e.g. ad libitum): Filtered tap water was supplied ad-libitum by an automatic water dispensing system.- Acclimation period: 20-28 daysENVIRONMENTAL CONDITIONS- Temperature (°C): 18-22 °C- Humidity (%): 33-68%- Photoperiod (hrs dark / hrs light): 12-hour light/dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Individual doses were calculated based on the initial body weights, taking into account the specific gravity (determined by PSL) of the test substance - Specific Gravity - 0.930 g/ml
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- An initial limit dose of 2,000 mg/kg of body weight was administered to one healthy female rat by oral gavage. Due to the absence of mortality in this animal, four additional females were sequentially dosed at the same dose level. Since all animals survived, no additional animals were tested.
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days - The animals were observed for mortality, signs of gross toxicity, and behavioral changes during the first several hours post-dosing and at least once daily thereafter for 14 days after dosing. Observations included gross evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity and behavior pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhea and coma.- Frequency of observations and weighing: Individual body weights of the animals were recorded prior to test substance administration (initial) and again on Days 7 and 14 or (termination) after dosing- Necropsy of survivors performed: yes
- Statistics:
- not applicable
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was noted during the study period.
- Clinical signs:
- Following administration, clinical signs noted for all animals included piloerection, facial staining, hypoactivity, andlor reduced fecal volume. However, all animals recovered by Day 2, and appeared active and healthy for the remainder of the 14-day observation period.
- Body weight:
All animals gained weight during the study period.- Gross pathology:
- No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the acute oral LD50 of Trirnethyl Borate is greater than 2000 mg/kg of body weight in female rats and as per Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, Trimethyl Borate will not be classified
- Executive summary:
An acute oral toxicity test (Up and Down Procedure) was conducted with rats to determine the potential for Trimethyl Borate (Lot# Lot #42Y4A09T, TD#04-001, >99% Trimethyl Borate) to produce toxicity from a single undiluted dose via the oral route. An initial limit dose of 2,000 mg/kg of body weight was administered to one healthy female rat by oral gavage. Due to the absence of mortality in this animal, four additional females were sequentially dosed at the same dose level. Since all animals survived, no additional animals were tested.
All animals survived exposure to the test substance and gained body weight. Following administration, clinical signs noted for all animals included piloerection, facial staining, hypoactivity, and/or reduced fecal volume. However, all animals recovered by Day 2, and appeared active and healthy for the remainder of the 14-day observation period. No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
Under the conditions of this study, the acute oral LD50 of Trirnethyl Borate is greater than 2000 mg/kg of body weight in female rats and as per Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, Trimethyl Borate will not be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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