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EC number: 244-479-6 | CAS number: 21615-47-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion (OECD 431): corrosive
Eye irritation /corrosion (OECD 405): corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 Mar 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
- Version / remarks:
- adopted in 2016
- Deviations:
- no
- GLP compliance:
- yes
- Test system:
- human skin model
- Source species:
- human
- Cell type:
- non-transformed keratinocytes
- Cell source:
- other: EpiDerm™ (EPI-200)
- Source strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on test system:
- RECONSTRUCTED HUMAN EPIDERMIS (RHE) TISSUE
- Model used: EpiDerm™(EPI-200) (MatTek Corporation, Ashland, MA, USA)
- Tissue batch number: 28302
- Production date: 22 Mar 2018
TEMPERATURE USED FOR TEST SYSTEM
- Temperature used during treatment / exposure: room temperature (3 min exposure); 37 °C (60 ± 1 min exposure)
REMOVAL OF TEST MATERIAL AND CONTROLS
-Volume and number of washing steps: Tissues were rinsed with PBS 20 times in order to remove any residual test material.
MTT DYE USED TO MEASURE TISSUE VIABILITY AFTER TREATMENT / EXPOSURE
- MTT concentration: 0.3 mL/well
- Incubation time: 180 ± 5 min
- Spectrophotometer: microplate reader (FLUOstar OPTIMA, BMG LABTECH)
- Wavelength: 570 nm
FUNCTIONAL MODEL CONDITIONS WITH REFERENCE TO HISTORICAL DATA
- Viability: The quality of the EpiDerm™ tissue was assessed by undertaking an MTT cell viability test. The determined OD (540 - 570 nm) was 1.708 ± 0.063 (acceptance criteria: 1.0 - 3.0).
- Barrier function: The barrier function was assessed by determination of the exposure time required to reduce tissue viability by 50% (ET-50) upon application of 100 µL of 1% Triton X-100. The ET-50 value was determined to be 6.42 h (acceptance criteria: 3.68-8.02 h).
- Contamination: The cells used to produce the EpiDerm™ tissue were screened for the presence of viruses, bacteria, yeast and other fungi.
NUMBER OF REPLICATE TISSUES: 2
CONTROL TISSUES USED IN CASE OF MTT DIRECT INTERFERENCE
Since the test substance showed no reducing capacity 1 h after MTT incubation, no additional test with freezekilled tissues had to be performed.
NUMBER OF INDEPENDENT TEST SEQUENCES / EXPERIMENTS TO DERIVE FINAL PREDICTION: single experiment
PREDICTION MODEL / DECISION CRITERIA
- The test substance is considered to be non-corrosive to skin if the viability after 3 min exposure is greater than 50% and the viability after 1 h exposure is greater than 15%.
- The test substance is considered to be corrosive to skin if the viability after 3 min exposure is less than 50%, or if the viability after 3 min exposure is greater than or equal to 50% and the viability after 1 h exposure is less than 15%. - Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- TEST MATERIAL
- Amount applied: 25 mg moistened with 25 µL distilled water
NEGATIVE CONTROL
- Amount applied: 50 µL
POSITIVE CONTROL
- Amount applied: 50 µL
- Concentration : 8 N - Duration of treatment / exposure:
- 3 min and 60 ± 1 min
- Number of replicates:
- duplicates for each treatment and control group
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- mean value of 2 tissues
- Run / experiment:
- 3 min exposure
- Value:
- 94.4
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Remarks:
- mean value of 2 tissues
- Run / experiment:
- 60 min exposure
- Value:
- 5
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Other effects / acceptance of results:
- OTHER EFFECTS:
- Direct-MTT reduction: The test substance showed no reducing capacity 1 hour after MTT incubation.
- Colour interference with MTT: The test substance did not change colour, when mixed with deionised water and thus passed the colour interference pre-test.
ACCEPTANCE OF RESULTS:
- Acceptance criteria met for negative control: The mean OD of the tissue replicates treated with the negative control was ≥ 0.8 and ≤ 2.8 for every exposure time (1.941 and 2.047).
- Acceptance criteria met for positive control: The mean viability of the tissue replicates treated with the positive control for 1 hour, was < 15% (1.4%) compared to the negative control.
- Acceptance criteria met for variability between replicate measurements: The Coefficient of Variation (CV) in the range 20 - 100% viability between tissue replicates was ≤ 30% (values between 0.1% and 11.74%) - Interpretation of results:
- other: Skin Corr. 1B/C according to Regulation (EC) No 1272/2008
- Conclusions:
- Under the conditions of the reconstructed human epidermis test cell viability after 3-min and 60-min exposure to the test substance were 94.4% and 5.0%, respectively.
Reference
Table 1. Results of skin corrosion test
3-min exposure | 60-min exposure | ||||||||||||||
OD a) | Cell viability (%) b) | SD c) | CV | OD a) | Cell viability (%) b) | SD c) | CV | ||||||||
Group | Tissue no. | Mean | Mean | Mean | Mean | ||||||||||
Negative control (Distilled water) | 1 | 1.937 | 1.939 | 1.941 | 99.9 | 100 | 0.14 | 0.1 | 2.026 | 2.03 | 2.047 | 99.2 | 100 | 1.13 | 1.1 |
1.937 | 2.031 | ||||||||||||||
1.942 | 2.032 | ||||||||||||||
2 | 1.938 | 1.942 | 100.1 | 2.07 | 2.063 | 100.8 | |||||||||
1.945 | 2.063 | ||||||||||||||
1.942 | 2.056 | ||||||||||||||
Positive control (KOH 8N) | 1 | 0.113 | 0.112 | 0.111 | 5.8 | 5.7 | 0.14 | 2.5 | 0.029 | 0.029 | 0.028 | 1.4 | 1.4 | 0.07 | 5.1 |
0.111 | 0.029 | ||||||||||||||
0.113 | 0.03 | ||||||||||||||
2 | 0.108 | 0.109 | 5.6 | 0.025 | 0.026 | 1.3 | |||||||||
0.111 | 0.025 | ||||||||||||||
0.109 | 0.027 | ||||||||||||||
Test substance (APFHx) | 1 | 1.68 | 1.671 | 1.833 | 86.1 | 94.4 | 11.74 | 12.4 | 0.103 | 0.103 | 0.102 | 5 | 5 | 0.07 | 1.4 |
1.669 | 0.104 | ||||||||||||||
1.665 | 0.103 | ||||||||||||||
2 | 1.983 | 1.994 | 102.7 | 0.095 | 0.1 | 4.9 | |||||||||
1.997 | 0.109 | ||||||||||||||
2.002 | 0.096 |
OD: optical density; SD: standard deviation; CV: coefficient of variation
a) OD value corrected by mean blank OD
b) Cell viability of negativ control was regarded as 100%.
c) The SD was calculated from the cell viabilities of each tissue insert (n=2).
Table 2. Historical control data (Jan 2016 - Feb 2018)
OD | ||||
3- min exposure | 60-min exposure | |||
Negative control | Positive control | Negative control | Positive control | |
Mean | 1.9 | 0.2006 | 1.852 | 0.065 |
SD | 0.192 | 0.069 | 0.191 | 0.031 |
Max | 2.331 | 0.371 | 2.176 | 0.113 |
Min | 1.635 | 0.028 | 1.573 | 0.024 |
Number of tests | 20 | 20 |
OD: optical density
SD: standard deviation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Feb - 05 Apr 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted in 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Version / remarks:
- adopted in 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Version / remarks:
- adopted in Nov 2000
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted in 2015
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- (SPF-Quality)
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Kisslegg, Germany
- Age at study initiation: 9 - 11 weeks
- Weight at study initiation: 2.049 - 2.330 kg (range)
- Housing: individually in cages with perforated floors (56x44x37.5 cm)
- Diet: standard laboratory rabbit diet (Charles River Breeding and Maintenance Diet for Rabbits, Altromin, Lage, Germany) approx. 100 g per day, additionally pressed hay three times a week
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16.5 - 24.7
- Humidity (%): 29 - 78
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The other eye of each animal remained untreated and served as the reference control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.1 mL - Duration of treatment / exposure:
- single application without washing
- Observation period (in vivo):
- 28 days
reading time points: 1, 24, 48 and 72 h and 7, 14, 21 days (and/or 28 days in the sentinel animal) - Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- SCORING SYSTEM: Draize scoring system
TOOL USED TO ASSESS SCORE: fluorescein; Where standard lighting was considered inadequate for observing minor effects, eye examinations were performed using an ophthalmic examination lamp. - Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 28 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 21 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: a 20% aqueous solution of the test substance was used
- Irritant / corrosive response data:
- The corneal injury consisted of opacity (maximum grade 2) in all animals and epithelial damage (maximum fluor area 35%, 65% and 50% of the corneal area). In 2/3 animals corneal injury was reversible within 7 days and persisted until day 21 in the remaining animal. lridial irritation (grade 1) was observed in all animals and was reversible within 72 hours in 1/3 animals and within 7 days in the two remaining animals. The irritation of the conjunctivae consisted of redness (maximum grade 3), chemosis (maximum grade 4) and discharge (maximum grade 3). Redness had completely resolved within 21 and 28 days in 2/3 animals, respectively, and persisted until termination (day 21) in the remaining animal. Chemosis and discharge had completely resolved within 7 days in all animals.
- Other effects:
- - Lesions and clinical observations: As a result of the corneal injury, pannus (neovascularisation of the cornea) was apparent in 1/3 animals 7 and 21 days after instillation. Reduced elasticity of the eyelids was noted in all animals 24 and/or 48 hours and/or 7 days after instillation.
- Other observations: No staining of (peri) ocular tissues by the test substance was observed and no test substance remnants were seen.
No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred. - Interpretation of results:
- other: Eye damage Cat. 1 according to Regulation (EC) No 1272/2008
- Conclusions:
- Under the conditions of this eye irritation study in rabbits the test substance was corrosive to the eye. Although a 20% aqueous solution of the test substance was used in this study, results are considered valid as corrosive properties can also be assumed for the pure test substance. Thus, the test substance is classified as Eye Dam. 1 (H318) according to Regulation (EC) No 1272/2008.
Reference
Table 1: Results of eye irritation study.
Alteration |
Animal No. |
Time (h) |
|||||
1 |
24 |
48 |
72 |
mean 24/48/72 h |
reversible within |
||
Cornea (opacity) |
1 |
1 |
2 |
1 |
1 |
1.3 |
7 days |
2 |
1 |
1 |
1 |
1 |
1.0 |
7 days |
|
3 |
1 |
1 |
1 |
1 |
1.0 |
Not reversible within 21 days |
|
Area of corneal opacity * |
1 |
1 |
1 |
2 |
1 |
- |
- |
2 |
3 |
3 |
3 |
2 |
- |
- |
|
3 |
3 |
2 |
2 |
2 |
- |
- |
|
Iris |
1 |
0 |
0 |
1 |
1 |
0.7 |
7 days |
2 |
1 |
1 |
1 |
0 |
0.7 |
72 h |
|
3 |
1 |
1 |
1 |
1 |
1.0 |
7 days |
|
Conjunctivae Redness |
1 |
2 |
2 |
3 |
3 |
2.7 |
28 days |
2 |
2 |
3 |
3 |
3 |
3.0 |
Not reversible within 28 days |
|
3 |
2 |
3 |
3 |
3 |
3.0 |
21 days |
|
Conjunctivae Chemosis |
1 |
4 |
3 |
2 |
1 |
2.0 |
7 days |
2 |
3 |
3 |
2 |
1 |
2.0 |
7 days |
|
3 |
3 |
2 |
2 |
1 |
1.7 |
7 days |
*Area of cornea involved:
0 = No ulceration or opacity
1 = One quarter or less but not zero
2 = Greater than one quarter, but less than half
3 = Greater than half, but less than three quarters
4 = Greater than three quarters, up to whole area
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin
In vitro
The skin corrosion potential of the test substance was assessed by an in vitro skin corrosion test using a human skin model (Reconstructed human Epidermis test method) according to OECD guideline 431 and in compliance with GLP (Miyaura, 2018). Each of two human skin tissues (EpiDerm™) were treated with 25 mg of the test substance moistened with 25 µL distilled water, the negative control (distilled water) or the positive control (potassium hydroxide 8 N) for 3 and 60 min, respectively. The cell viability was measured by dehydrogenase conversion of MTT into a blue formazan salt that was quantitatively measured after extraction from tissues. The relative mean tissue viabilities obtained after 3 and 60 min treatment with the test substance compared with the negative control tissues were 94.4% and 5.0%, respectively. As the mean relative tissue viability for the test substance was below 15% after 60 min treatment the test substance was considered to be corrosive to the skin. The optical pre-experiment (colour interference pre-experiment) did not lead to a change in colour by the test substance. Additionally, optical evaluation of the MTT-reducing capacity of the test substance after 1 hour incubation with MTT-reagent did not show blue colour. The positive control, potassium hydroxide, had a mean cell viability of 1.4% (required ≤ 15%) after 60 min exposure; showing the validity of the test system. All other acceptability criteria were met. Based on the results of this study, the test substance was corrosive to the skin under the conditions of the test. This leads to the classification Skin Corrosion 1B/C.
In vivo
The skin irritation potential of a 20% solution of the test substance was determined in an in vivo skin irritation/corrosion test performed in three albino rabbits according to OECD guideline 404 and in compliance with GLP (Teunissen, 2004). In a first step, one rabbit was exposed to three samples of 0.5 mL of the test substance on the clipped skin using semi-occlusive dressings. After exposure periods of 3 min, 1 h and 4 h, respectively, the patch was removed and the treated areas were rinsed with water. Local skin irritation effects were scored 1, 24, 48 and 72 h and 7 days after patch removal using the Draize scoring system. Based on the absence of severe skin reactions, two further animals were exposed for 4 hours to the test substance in a next step. After 4 h exposure, well-defined erythema (score 2) was observed in 3/3 animals, fully reversible in all animals within 7 days. Very slight edema (score 1) was observed in 3/3 animals, reversible in all animals within 48 h. Mean scores for 24, 48 and 72 h were 1.7, 1.7 and 1.7 for erythema and 0.3, 0.3 and 0.3 edema for the 3 rabbits, respectively. Since the study was conducted with a 20% aqueous solution of the test substance, this study cannot be used for classification purposes.
Eye, in vivo
The eye irritation/corrosion potential of a 20% solution of the test substance was assessed in three albino rabbits according to OECD guideline 405 and in compliance with GLP (Teunissen, 2003). 0.1 mL of the test substance was instilled in one eye of each animal. The other eye remained untreated and served as control. The eyes were examined and scored according to Draize 1, 24, 48 and 72 h and 7, 14, 21 and/or 28 days after application. After instillation of the test substance corneal opacity (maximum grade 2) and epithelial damage (maximum fluor area 35%, 65% and 50% of the corneal area) was observed in all animals. As a result of the corneal injury, pannus (neovascularisation of the cornea) was apparent in one animal up to 21 days after instillation. In 2/3 animals corneal injury was reversible within 7 days. lridial irritation (grade 1) was observed in all animals and was reversible within 72 h in 1/3 animals and within 7 days in the two remaining animals. The irritation of the conjunctivae consisted of redness (maximum grade 3), chemosis (maximum grade 4) and discharge (maximum grade 3). Redness had completely resolved within 21 and 28 days in 2/3 animals, respectively, and persisted until termination (Day 21) in the remaining animal. Chemosis and discharge had completely resolved within 7 days in all animals. Reduced elasticity of the eyelids was noted 24 and/or 48 hours and/or 7 days after instillation. Mean scores for 24, 48 and 72 h were 1.33, 1 and 1 for corneal opacity, 0.67, 0.67 and 1 for iris score, 2.67, 3 and 3 for conjunctivae score and 2, 2 and 1.67 for chemosis score for the 3 animals, respectively. Based on the results of this study, the test substance is considered to be corrosive to the eye under the conditions of the test. Although a 20% aqueous solution of the test substance was used in this study, corrosive properties can also be assumed for the pure test substance. This leads to the classification Eye Dam. 1.
Justification for classification or non-classification
The available data on skin and eye irritation/corrosion of the test substance meet the criteria for classification as Skin Corr. 1B/C (H314) and Eye Dam. 1 (H318) according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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