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EC number: 213-361-6 | CAS number: 939-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Isopropyl benzoate is not irritating to the skin or eye of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- Pre-existing in vivo study.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to GLP, however, documentation is incomplete.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
No details on the test animals were provided in the report. - Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- 0.5 ml
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): None
VEHICLE: None - Duration of treatment / exposure:
- 4 hours. After 4 hours of exposure the skin was cleaned and decontaminated with water.
- Observation period:
- 1 hr and 1, 2 and 3 days after exposure.
- Number of animals:
- Three
- Details on study design:
- - Area of exposure: Shaved flank
REMOVAL OF TEST SUBSTANCE
- Washing with water: Yes
- Time after start of exposure: 4 hrs
SCORING SYSTEM:
Draize scale - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: Mean scores calculated from 1, 2 and 3 day readings
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: No measurable erythema or edema
- Irritant / corrosive response data:
- There was no measurable irritation or corrosive response on three rabbits tested.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance was non-irritating following a single four hour application to rabbit skin. The test was conducted on three rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Remarks:
- Pre-existing in vivo study.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental studies were performed in a reliable research institute prior to establishment of international guidelines and GLP
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Precedes establishment of guideline and GLP. It is assumed that this scientific study was performed according to the accepted standards of its day.
- GLP compliance:
- no
- Remarks:
- Precedes establishment of GLP
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- no data
- Amount / concentration applied:
- 5 microliters
- Observation period (in vivo):
- 24 h after instillation
- Number of animals or in vitro replicates:
- 5
- Details on study design:
- Five albino rabbits are selected. Prior to administering the test material, the animals are selected based on an absence of grossly visible staining in the eye by a 5% aqueous solution of fluorescein sodium, flushed with distilled water 20 seconds after application. After a two hour interval allowing the eye to return to normal, 0.005 ml of undiluted material is administered while the eye lid is retracted; about 1 minute later, the lids are released. Assessment of injury occurs 18-24 hours after administration, in strong diffuse daylight and then in an examination aided with fluorescein. The injury is then scored. A level of 5 (of 20) is representative of severe injury, corresponding to necrosis covering about 75% of cornea or a smaller area of more severe necrosis. Guided by the result and the table of injury grades, additional applications are made. The average injury score per animal is divided by 5 (number of animals) and assigned a grade. If dilution of a chemical is necessary, the preferred solvent is propylene glycol, and then water.
- Irritation parameter:
- overall irritation score
- Remarks:
- non-standard scale
- Basis:
- mean
- Time point:
- other: 24 h after application
- Score:
- 1
- Max. score:
- 20
- Reversibility:
- not specified
- Remarks on result:
- other: low irritation
- Irritant / corrosive response data:
- Using a non-standard scale to evaluate eye irritation, the score was 1 (of 20 maximum) at 24 h after application of IPB.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Using a non-standard scale to evaluate eye irritation in rabbits, the score was 1 (of 20 maximum) at 24 h after application of IPB.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
experimental data
Justification for selection of eye irritation endpoint:
experimental data
Justification for classification or non-classification
Considering that isopropyl benzoate is not irritating to the skin or eye of rabbits, and that is has a long history of safe use in cosmetic ingredients in the EU and other jurisdictions, the substance is not classified for irritation or corrosion, according to Regulation EC No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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