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Diss Factsheets
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EC number: 278-305-5 | CAS number: 75768-65-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
read accross with analogue source substance:
Non-sensitising; OECD 406 ; Drs. A.H.B.M. van Huygevoort., 2001c
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A preliminary irritation study was conducted using 3 individuals in order to select the test substance concentrations to be used in the main study. The results concluded that intradermal injections at a concentration of 1 % test item and epidermal application at a concentration of 50 % test item were the highest concentrations that produced moderate irritation. These concentrations were therefore assigned in the induction phase of the main test. The highest epidermal concetration applied that did not cause irritation was 5 % test item. This concetration was therefore assigned in the challenge phase of the main test.
The main test was conducted using 15 individuals, 5 controls and 10 treated. On Day 1, each individual was subjected to three pairs of intradermal injection around the scapular region (0.1 mL/ site); 2 x 1:1 FCA:water, 2 x 1 % test item in corn oil (or corn oil only for controls), 2 x 1 % test item in FCA (1:1 mix) (corn oil: FCA mix for controls). The dermal reactions cused by the injections were assessed on Day 3 for irritation. On Day 8, the scapular region was clipped and a dermal application (0.5 mL) of the test item (50 % concentration) was applied (2 x 3 cm patch) between the injection sites. The patch was held in place for 48 using micropore tape and an elastic bandage. The patches were removed and the applications sites cleaned prior to assessment. On Day 21 each individual recieved a challenge dermal application, that was applied as previously described, at a concetration of 5 %. The patch was removed after 24 h contact time, the skin cleaned and assessment for irritation made at 24 and 48 h (after challenge application).
The results of the main studies showed moderate erythema (grade 3) at the injection and dermal patch sites after the induction of the test item at a concentration of 1 % and 50 %, respectively. It should be noted that signs of necrosis was observed in 2 treated individuals after the dermal induction phase. No skin reactions were observed following the challenge phase in any of the individuals. No mortality or systemic toxicity were observed during the main test and body weight increases in the treated individuals was in the same range as the controls.
In this study, Bisphenol AF is not a dermal sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The substance does not meet the classification criteria for skin sensitisation in accordance with Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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