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EC number: 226-827-9 | CAS number: 5495-84-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Remarks:
- Skin irritation study in humans
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- August 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
- Study type:
- other: patch test
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A 48-hour patch test was carried out on 10 volunteers at the Consumer Research Unit, Morningside, Edinburgh, field station of Inveresk Research International Limited. The irritation potential was evaluated following 2 consecutive 23h applications to skin with assessment of reactions 1h after each patch removal.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-isopropyl-9H-thioxanthen-9-one
- EC Number:
- 226-827-9
- EC Name:
- 2-isopropyl-9H-thioxanthen-9-one
- Cas Number:
- 5495-84-1
- Molecular formula:
- C16H14OS
- IUPAC Name:
- 2-isopropyl-9H-thioxanthen-9-one
- Test material form:
- solid: particulate/powder
Constituent 1
Method
- Type of population:
- general
- Subjects:
- 10 volunteers at the Consumer Research Unit, Morningside, Edinburgh, field station of Inveresk Research International Limited
- Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- Test material was applied in approximatey 0.2 g amounts to 2 cm x 2 cm squares backed by Blenderm adhesive tape. The webril square was moistened with 0.3 ml of distilled water prior to application to the skin.
A patch strip contained 2 Webril squares and 2 patch strips comprised a patch scheme. The order of test meaterials applied to the patch scheme was randomised in 4 different ways to eliminate position and order bias.
Both patch strips were applied in parallel down the upper outer left arm of each volunteer. Approximately 23h after patch application the volunteers removed the patch scheme and washed off any excess test material with a water dampened tissue. - Examinations:
- Reactions were assessed 1h later by a trainer assessor following a scoring system (scales of 0 to 8 for erythema and dryness). An identical patch scheme was then applied to the same area for a further period of 23h. Skin reactions were again assessed 1h after patch removal.
- Medical treatment:
- none
Results and discussion
- Clinical signs:
- none
- Results of examinations:
- no skin reaction was observed with ITX.
Mean Erythema score at 48h : 0
Mean Dryness score at 48h : 0.05
Applicant's summary and conclusion
- Conclusions:
- No skin irritation was observed after ITX exposure.
- Executive summary:
A 48-hour patch test was carried out on 2 volunteers at the Consumer Research Unit, Morningside, Edinburgh, field station of Inveresk Research International Limited. The irritation potential was evaluated following 2 consecutive 23h applications to skin with assessment of reactions 1h after each patch removal.
No skin irritation was observed after ITX exposure.
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