Registration Dossier
Registration Dossier
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EC number: 257-913-4 | CAS number: 52434-90-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 September 2022 to 10 September 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 4.31
- Temp.:
- 30 °C
- Remarks on result:
- other: pH not provided in the study report as buffer was not used for mobile phase preparation
- Conclusions:
- The mean partition coefficient (mean log Pow) of AP 729 was found to be 4.31 at 30°C.
- Executive summary:
The partition coefficient of test item AP 729 was determined in the present study according to OECD Test Guideline 117 (HPLC method).
The dead time t0 was determined by using Thiourea as unretained substance.
Six reference standards of known log Pow and the test item were analyzed by HPLC: the retention times were determined and the capacity factors ‘k’ were calculated.
The partition coefficient of the test item AP 729 was obtained by interpolation of the calculated capacity factor ‘k’ on the calibration graph of ‘log k’ versus ‘log Pow’ for the reference substances with appropriate ‘log Pow’ values.
The partition coefficient (log Pow)of AP 729 was found to be 4.31 for Replication 1 and 4.31 for Replication 2.The mean partition coefficient of AP 729 (log Pow) was 4.31 at 30°C.
Reference
Description of key information
The partition coefficient of test item AP 729 was determined according to OECD Test Guideline 117 (HPLC method).
The mean partition coefficient of AP 729 (log Pow) was 4.31 at 30°C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.31
- at the temperature of:
- 30 °C
Additional information
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