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Diss Factsheets
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EC number: 236-885-7 | CAS number: 13532-94-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- other: Expert assessment
- Adequacy of study:
- key study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment of the toxicokinetics behaviour of the substance was performed using results from existing toxicological studies and its physicochemical profile
- Objective of study:
- toxicokinetics
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment of the toxicokinetics behaviour of the substance was performed using results from existing toxicological studies and its physicochemical profile
- GLP compliance:
- no
- Type:
- excretion
- Results:
- No data investigating the excretion of 2-butoxyethyl methacrylate were identified.
Excretion via urine is very likely due to its low molecular weight (< 300 g/mol) and water solubility. - Type:
- metabolism
- Results:
- No data investigating the metabolisation of 2-butoxyethyl methacrylate were found.
Small quantities of methacrylates may readily be metabolized by saponification into methacrylic acid and alcohol. - Type:
- distribution
- Results:
- 2-butoxyethyl methacrylate is a hydrophilic substance with a low molecular weight, therefore, it is expected to be well-distributed in a mammalian body through the water compartments but is not expected to accumulate in tissues
- Type:
- absorption
- Results:
- Adsorption via the oral route is expected and was confirmed by experimental data. Dermal absorption through skin is likely to occur. However, its penetration into the skin is expected to be limited. No absorption via inhalation is expected
- Details on absorption:
- Oral exposure: 2-butoxyethyl methacrylate is an organic substance with a low molecular weight (186.25 g/mol) and moderate solubility in water (395.7 mg/L). It can be expected that 2-butoxyethyl methacrylate is absorbed passively through GI epithelial tissue.
A Log Kow of 2.47 was predicted for 2-butoxyethyl methacrylate using a QSAR model. This value is between -1 and 4 and therefore supports the fact that the substance is likely to be absorbed by passive diffusion following oral exposure.
An acute toxicity study was performed on 2-butoxyethyl methacrylate via the oral route. At necropsy, signs of systemic toxicity were observed indicating that the substance has been absorbed.
Inhalation exposure: 2-butoxyethyl methacrylate has a vapour pressure of <0.99 hPa=0.099 kPa and a boiling point of 228°C at 101.325 kPa. According to ECHA (2017), only highly volatile substances (with vapour pressure greater than 25 kPa and boiling point of <50°C) may be available for respiratory absorption. Therefore, no exposure via inhalation to this substance is expected.
There is no data available investigating the toxicokinetic behaviour of the substance following an inhalation exposure.
There is no data available on the effects of the substance following an inhalation exposure.
Dermal exposure: The substance has a molecular mass of 186.25 so it could theoretically be absorbed following dermal exposure (Bos et al., 2000). However, its dermal penetration would be limited by its molecular mass being above 100 Da (ECHA, 2017).
According to ECHA (2017), the acrylate group may decrease the uptake of the substance due to binding to skin components.
Water solubility of the 2-butoxyethyl methacrylate (395.7 mg/L) is in the range of 100-1,000 mg/L which indicates a moderate to high absorption through skin.
The 2-butoxyethylmethacrylate is irritant to skin, therefore, irritation may increase the dermal absorption of this substance.
Considering the physicochemical properties of the 2-butoxyethyl methacrylate, absorption through skin is likely to occur. However, its penetration into the skin is expected to be limited because stratum corneum has a lipophilic nature that resists penetration of hydrophilic compounds. There is no data available on the systemic effects of the substance following a dermal exposure. - Details on distribution in tissues:
- Since 2-butoxyethyl methacrylate is a hydrophilic substance with a low molecular weight, it is expected to be well-distributed in a mammalian body through the water compartments but is not expected to accumulate in tissues (ECHA, 2017).
An acute toxicity study performed on the substance showed mottled lungs and discoloured liver, indicating exposure of these organs to the substance - Details on excretion:
- No data investigating the excretion of 2-butoxyethyl methacrylate were identified.
Excretion via urine is very likely due to its low molecular weight (< 300 g/mol) and water solubility. - Metabolites identified:
- not measured
- Details on metabolites:
- No data investigating the metabolisation of 2-butoxyethyl methacrylate were found.
Small quantities of methacrylates may readily be metabolized by saponification into methacrylic acid and alcohol. Methacrylic acid forms an acetyl-coenzyme A derivative which then enters the normal lipid metabolism (Clayton and Clayton, 1981-1982). - Conclusions:
- An assessment of the toxicokinetics behaviour of the substance was performed using results from
existing toxicological studies. - Executive summary:
An expert review of the toxicokinetic profile of the test substance was assessed based on physicochemical profile and availabel toxicity data.
The absence of specific toxicokinetics data from animal testing means that it is not possible to make firm conclusions concerning the absorption, distribution, metabolisation and excretion of 2-Butoxyethyl methacrylate.
However, it can be expected that the substance will be absorbed following an exposure via the oral route, which is supported by a result on an animal study performed on the substance using this route of exposure. No exposure to the substance via inhalation as a vapour is expected. In regards to the
dermal route, partition coefficient and water solubility of 2-butoxyethyl methacrylate (395.7 mg/L) indicates a moderate to high absorption through skin.Absorbed test substance is expected to be excreted via the kidneys into the urine due to its low molecular weight (< 300 g/mol) and water solubility.
There is no expectation that the test substance will preferentially distribute to particular organs or tissues in the body. 2-butoxyethyl methacrylate is expected to be well-distributed in the human body due to its low molecular weight and high-water solubility but it is not expected to accumulate. Available animal data on the substance do not provide evidence to support this prediction.
Reference
Description of key information
An expert review of the toxicokinetic profile of the test substance was assessed based on physicochemical profile and available toxicity data.
The absence of specific toxicokinetics data from animal testing means that it is not possible to make firm conclusions concerning the absorption, distribution, metabolisation and excretion of 2-Butoxyethyl methacrylate.
However, it can be expected that the substance will be absorbed following an exposure via the oral route, which is supported by a result on an animal study performed on the substance using this route of exposure. No exposure to the substance via inhalation as a vapour is expected. In regards to the
dermal route, partition coefficient and water solubility of 2-butoxyethyl methacrylate (395.7 mg/L) indicates a moderate to high absorption through skin.
Absorbed test substance is expected to be excreted via the kidneys into the urine due to its low molecular weight (< 300 g/mol) and water solubility.
There is no expectation that the test substance will preferentially distribute to particular organs or tissues in the body. 2-butoxyethyl methacrylate is expected to be well-distributed in the human body due to its low molecular weight and high-water solubility but it is not expected to accumulate. Available animal data on the substance do not provide evidence to support this prediction.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.