Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-703-2 | CAS number: 1644-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 April 2017 - 11 May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,1,2,3,3-hexafluoro-2-(heptafluoropropoxy)-3-[(trifluorovinyl)oxy]propane
- EC Number:
- 216-703-2
- EC Name:
- 1,1,1,2,3,3-hexafluoro-2-(heptafluoropropoxy)-3-[(trifluorovinyl)oxy]propane
- Cas Number:
- 1644-11-7
- Molecular formula:
- C8F16O2
- IUPAC Name:
- 1,1,1,2,2,3,3-heptafluoro-3-({1,1,1,2,3,3-hexafluoro-3-[(1,2,2-trifluoroethenyl)oxy]propan-2-yl}oxy)propane
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 116B2018
- Physical state: clear and colorless liquid
- Analytical purity: 96.3%
- Expiration date of the lot/batch: 31 August 2018
- Purity test date: 15 Nov 2016
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature container flushed with nitrogen
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge from the 'Waterschap Aa en Maas' municipal sewage treatment plant ('s-Hertogenbosch, The Netherlands), receiving predominantly domestic waste. Suspended solids concentration was 4.0 g/L from the plant.
- Storage conditions: Continuous aeration until use.
- Storage length: Not reported ("freshly obtained")
- Preparation of inoculum for exposure: Sludge allowed to settle 33 minutes and liquid decanted for use as inoculum.
- Pretreatment: None
- Concentration of sludge: 10 mL/L mineral medium - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 20 mg/L
- Based on:
- other: organic carbon
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral medium as per method TG310, water was purified by reverse osmosis and subsequently passed over activated carbon and ion-exchange cartridges (MIllipore, Bedford, MA, USA)
- Solubilising agent (type and concentration if used): none
- Test temperature: 20 - 21 °C
- pH: 7.8 at beginning of test
- pH adjusted: no
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: septum-sealed glass bottles
- Number of culture flasks/concentration: triplicate bottles for days 8, 14, and 21, five bottles for day 28
- Method used to create aerobic conditions: Test was performed in sealed bottles with a headspace:medium ration of 1:2 to provide a reservoir of oxygen adequate for the duration of the exposure.
- Measuring equipment: Equipment as detailed
- Test performed in closed vessels due to significant volatility of test substance: Yes
- Details of trap for CO2 and volatile organics if used: Closed bottle test. Evolved CO2 was forced into the test medium by the addition of 1 mL 7M NaOH.
SAMPLING
- Sampling frequency: Days 8, 14, 21, and 28
- Sampling method: bottles sacrificed and analyzed as detailed
- Sterility check if applicable: None
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes, sampled at each time point
- Abiotic sterile control: yes, inoculum free sample additionally treated with 1 mL/L of a 10 g/L solution of HgCl2 (sampled on day 28 only)
- Toxicity control: Yes, reference substance and PPVE-2, each at 20 mg C/L (sampled on Days 8 and 14 only)
- Positive control: Sampled on Days 8 and 14 only
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- ca. 0
- Sampling time:
- 28 d
- Remarks on result:
- other: Not significantly different than blanks
- Details on results:
- Average inorganic carbon (IC) concentration in blanks (Table 1) on Day 28 was 1.623 mg/L (SD, 0.178 mg/L). Average IC concentration in PPVE-2 bottles (Table 2) on Day 28 was 1.718 mg/L (SD, 0.129 mg/L). The two averages are not significantly different according to Student's T-test (P = 0.36). Therefore, there was no significant biodegradation of PPVE-2 (statistics calculated for this study summary)
The reference substance was 71% degraded by day 14 (Table 3). Inorganic carbon concentrations in positive control and toxicity control (Table 3) were not significantly different on Day 8 (P = 0.87) or Day 14 (P = 0.91). Therefore, there was no significant effect of PPVE-2 on degradation in this study (statistics calculated for this summary with assumption that all IC in toxicity control was from degradation of the reference substance).
Any other information on results incl. tables
Table 1, Individual concentrations of inorganic carbon (IC) in mg/L for the blank control during the biodegradation test.
Day |
Bottle 1 |
Bottle 2 |
Bottle 3 |
Bottle 4 |
Bottle 5 |
Mean |
Std. dev. |
8 |
1.310 |
1.195 |
1.205 |
─ |
─ |
1.237 |
0.064 |
14 |
1.610 |
2.097 |
1.910 |
─ |
─ |
1.872 |
0.246 |
21 |
1.931 |
1.950 |
1.860 |
─ |
─ |
1.914 |
0.047 |
28 |
1.926 |
1.521 |
1.551 |
1.485 |
1.633 |
1.623 |
0.178 |
Table 2, Individual concentrations of inorganic carbon (IC) in mg/L for PPVE-2 during the biodegradation test.
Day |
Bottle 1 |
Bottle 2 |
Bottle 3 |
Bottle 4 |
Bottle 5 |
Mean |
Std. dev. |
Percent degradation |
8 |
1.276 |
1.278 |
1.342 |
─ |
─ |
1.299 |
0.038 |
0 |
14 |
1.577 |
3.076 |
3.516 |
─ |
─ |
2.723 |
1.017 |
4 |
21 |
1.906 |
1.914 |
1.995 |
─ |
─ |
1.938 |
0.049 |
0 |
28 |
1.726 |
1.919 |
1.565 |
1.718 |
1.663 |
1.718 |
0.129 |
0 |
Table 3, Individual concentrations of inorganic carbon (IC) in mg/L for positive control (R), toxicity control (T), and abiotic control (C) during the biodegradation test.
Day |
Bottle 1 |
Bottle 2 |
Bottle 3 |
Bottle 4 |
Bottle 5 |
Mean |
Std. dev. |
Percent degradation |
R8 |
11.64 |
13.16 |
11.21 |
─ |
─ |
12 |
1.025 |
54 |
R14 |
16.70 |
15.69 |
15.18 |
13.84 |
18.97 |
16.08 |
1.918 |
71 |
T8 |
12.82 |
14.33 |
9.658 |
─ |
─ |
12.27 |
2.384 |
28 |
T14 |
15.32 |
16.54 |
21.62 |
13.14 |
12.69 |
15.86 |
3.584 |
35 |
A28 |
0.9115 |
0.8278 |
1.051 |
0.7894 |
0.6796 |
0.8519 |
0.1391 |
-4 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- < 3 mg/L inorganic carbon in blanks at end of test, reference substance > 60% degraded by day 14
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- PPVE-2 is not readily biodegradable
- Executive summary:
Ready biodegradability of PPVE-2 was studied in a test done according to OECD TG310. PPVE-2, sodium benzoate (reference substance), or both chemicals (toxicity control) were introduced to test bottles at 20 mg/L theoretical organic carbon (ThOC). Bottles also contained mineral medium inoculated with activated sludge from a predominantly domestic source. Blank bottles containing only inoculated medium were also prepared. Bottles were sacrificed at intervals by addition of 7M NaOH to draw evolved CO2 into the mineral medium. After equilibration, CO2 concentrations were measured using a carbon analyzer. No statistical difference was found between blanks and PPVE-2 bottles. The blank bottles had < 3 mg/L inorganic carbon, and the reference substance was >60% degraded by day 14. Assuming that all inorganic carbon in the toxicity control was due to sodium benzoate, there was no statistical difference between the positive control and the toxicity control. PPVE-2 did not inhibit activated sludge in this assay. PPVE-2 was not biodegraded in this assay. PPVE-2 is not readily biodegradable.
This test was conducted under an internationally accepted guideline for volatile chemicals, and was in accord with GLP criteria. Therefore, this study is reliable without restrictions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.