(2S,3S)-2,3-Bis[(4-methylbenzoyl)oxy]butanedioic acid — methyl {(4S)-8-fluoro-2-[4-(3methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4yl}acetate — ethyl acetate (1:1:1)

Guidance on Safe Use

First-aid measures

Inhalation:

Move into fresh air and keep at rest. For breathing difficulties, oxygen may be necessary. Get medical attention. If breathing stops, provide artificial respiration.

Eye contact:

Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contact lenses. Get medical attention.

Skin contact:

Wash skin thoroughly with soap and water. Get medical attention if irritation persists after washing. Remove contaminated clothing and shoes. Wash contaminated clothing before reuse. Destroy or thoroughly clean contaminated shoes.

Ingestion:

Do not induce vomiting unless directed to do so by medical personnel. Never give liquid to an unconscious person. Get medical attention.

Fire-fighting measures

General fire hazards:

Self-contained breathing apparatus and full protective clothing must be worn in case of fire.

Suitable extinguishing media:

Water spray, fog, CO2, dry chemical, or alcohol resistant foam

Unsuitable extinguishing media:

None known.

Special hazards arising from the substance or mixture:

Emits toxic fumes under fire conditions.

Special protective equipment for fire-fighters:

Prevent runoff from fire control or dilution from entering streams, sewers, or drinking water supply.

Accidental release measures

Personal precautions, protective equipment and emergency procedures:

Use personal protective equipment. Immediately contact emergency personnel. Keep unnecessary personnel away. Follow all fire fighting procedures.

Environmental precautions:

Do not release into the environment

Methods and material for containment and cleaning up:

Use a vacuum cleaner. If not possible, moisten dust with water before it is collected with shovel, broom or the like. Collect in containers and seal securely. For waste disposal, see section 13 of the MSDS. Prevent runoff from entering drains, sewers, or streams.

Handling and storage

Precautions for safe handling:

Do not breathe dust. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling.

Conditions for safe storage, including any incompatibilities:

Keep container tightly closed in a cool, well-ventilated place.

Transport information

Land transport (UN RTDG/ADR/RID)

Shipping

Special provisions / remarks

Remarks:

Not regulated for transport.

Inland waterway transport (UN RTDG/ADN(R))

Shipping

Special provisions / remarks

Remarks:

Not regulated for transport.

Marine transport (UN RTDG/IMDG)

Shipping

Special provisions / remarks

Remarks:

Not regulated for transport.

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Not regulated for transport.

SpecialProvisions

Exposure controls / personal protection

Appropriate engineering controls:

Minimize open handling. Containment technologies suitable for controlling compounds are required to control at source and to prevent migration of the compound to uncontrolled areas (e.g., open-face containment devices).

General information:

Reference: Directive 89/686/EEC. Observe occupational exposure limits and minimize the risk of inhalation of dust.

Eye/face protection:

Reference standard: EN 166. Wear safety glasses with side shields (or goggles). If the work environment or activity involves dusty conditions, mists or aerosols, wear the appropriate goggles. Wear a faceshield or other full face protection if there is a potential for direct contact to the face with dusts, mists, or aerosols.

Hand protection:

Reference standard: EN 374. Chemical resistant gloves. Consider double gloving.

Other:

Additional body garments should be used based upon the task being performed (e.g., sleevelets, apron, gauntlets, disposable suits) to avoid exposed skin surfaces. Use appropriate degowning techniques to remove potentially contaminated clothing.

Respiratory Protection:

Reference standard: EN 140. Use an appropriate approved air-purifying respirator equipped with HEPA cartridges/canisters where there is the potential for exceeding established occupational exposure limits or occupational exposure bands. Reference standard: EN 12941. Powered air filter respirator. Reference standard: EN 14594. Use a positive pressure, air-supplied, pressure demand tight fitting respirator (e.g., SCBA or airline equipped with emergency escape bottle) where there is a potential for

uncontrolled releases in excess of the respirator's capabilities, where exposure levels are unknown or where air-purifying respirators may not provide adequate protection.

Hygiene measures:

Wash skin thoroughly with soap and water.

Stability and reactivity

Chemical stability: Stable.

Possibility of hazardous reactions: Stable

Conditions to avoid: Excessive heat. Moisture.

Hazardous decomposition products: Thermal decomposition or combustion may liberate carbon oxides and other toxic gases or vapors.

Disposal considerations

General information: Incineration is the most effective method of disposal in most instances. Do not allow runoff to sewer, waterway or ground. Operations that involve the crushing or shredding of waste materials or returned goods should take into

account recommended exposure limits where they exist.

Disposal Methods: Disposal must be in accordance with applicable national, state/provincial, and/or local regulations.