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Diss Factsheets
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EC number: 202-495-0 | CAS number: 96-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
TG has an oral LD50 of 648 mg/kg bw. The percutaneous LD50 is 683 mg/bw.
The 4-h LC50, read-across from GMT, is 0.51 mg/L
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- study was conducted prior to the GLP legislation
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- Batch 297-1382
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- BW: 200-300 g
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- except for 0.05 and 0.25 mg/kg dose, which were administered as 1% solution in water
- Details on oral exposure:
- animals were fasted for 24 h before dosing
- Doses:
- 0.05, 0.25, 0.50, 1.00, 5.00 mL/kg bw
62, 312, 623, 1247, 6234 mg/kg bw (using density of 1.25 g/mL) - No. of animals per sex per dose:
- 5 (3m / 2f)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Probit analysis (Miller & Tainter, Proc Soc Biol Med 57, 261 (1944))
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 0.52 mL/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 648 mg/kg bw
- Based on:
- test mat.
- Mortality:
- mg/kg bw dead total mortality
62 0 5 0%
312 0 5 0%
623 2 5 40%
1247 5 5 100%
6234 5 5 100% - Clinical signs:
- other: not reported
- Gross pathology:
- not reported
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on an LD50 of 648 mg/kg bw, monothioglycerol should be classified as Acute Tox 4 - H302: Harmful if swallowed
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 648 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see attached justifications
- Reason / purpose for cross-reference:
- read-across source
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- inhalation: aerosol
- Duration of exposure:
- 1 h
- Concentrations:
- 2.04 mg/L nominal concentration
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- >= 2.04 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.04 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.51 mg/L air
- Based on:
- other: extrapolation using Haber's Law
- Exp. duration:
- 4 h
- Mortality:
- none
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The extrapolated 4-h LC50 of GMT is greater than 0.51 mg/L, but it is assumed that the 4-h LC50 for monothioglycerol could be below 1 mg/L.
Thus, monothioglycerol should be classified as Acute Tox 3 - H331: Toxic if inhaled
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 510 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CCFR 1500.40
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- study was conducted prior to the GLP legislation
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- Batch 297-1382
- Species:
- rabbit
- Strain:
- other: Albino, not further specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- not reported
- Doses:
- 0.2, 0.50, 0.75, 1.00, 2.00 mL/kg bw
249, 623, 935, 1247, 2494 mg/kg bw (using density of 1.25 g/mL) - No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 0.54 mL/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 673 mg/kg bw
- Based on:
- test mat.
- Mortality:
- mg/kg bw Dead total Mortality
249 0 5 0%
623 2 5 40%
935 4 5 80%
1247 5 5 100%
2494 5 5 100% - Clinical signs:
- other: not reported
- Gross pathology:
- not reported
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Based on an LD50 of 673 mg/kg bw, monothioglycerol should be classified as Acute Tox 3 - H311: Toxic in contact with skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 673 mg/kg bw
Additional information
Justification for classification or non-classification
Based on an LD50 of 648 mg/kg bw, monothioglycerol should be classified as Acute Tox 4 - H302: Harmful if swallowed
The extrapolated 4-h LC50 read-across from GMT is greater than 0.51 mg/L, but it is assumed that the 4-h LC50 for monothioglycerol could be below 1 mg/L. Thus, monothioglycerol should be classified as Acute Tox 3 - H331: Toxic if inhaled
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