Registration Dossier
Registration Dossier
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EC number: 237-758-9 | CAS number: 13977-56-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
In order to evaluate toxicological properties of the substance iron vanadium tetraoxide, information on the assessment entities iron ions (i.e. diiron trioxide) and vanadium ions were considered. For a documentation and justification of that approach, please refer to the separate document attached to section 13, namely Read Across Assessment Report for iron vanadium tetraoxide.
The toxicity of iron vanadium tetraoxide may reasonably be considered to be determined by the bioavailability of the assessment entity "vanadium ions" since there are not any indications that the assessment entity “iron ions” (i.e. diiron trioxide) would be classified as hazardous for human health under Regulation (EC) No 1272/2008. Further, iron should be considered void of genotoxicity based on its essentiality and a weight of evidence approach using two bacterial reverse mutation assays. Based on the available weight-of-evidence, and considering guideline-conform studies conducted under GLP both in vitro as well as in vivo, vanadium ions should also be considered void of genotoxicity. Similarly, classification of iron vanadium tetraoxide with respect to a mutagenic potential does not appear to be supported. Thus, according to EC Regulation No. 1272/2008, iron vanadium tetraoxide should not be considered to have a mutagenic potential, and hence classification or labelling is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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