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EC number: 249-576-7 | CAS number: 29340-81-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See read-across record in section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Result from read-across source substance Cas No. 30798-32-4
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 609.88 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% confidence interval 565.2 mg/L - 658.3 mg/L
- Remarks:
- Result from read-across source substance CAS No. 102-71-6
Reference
Description of key information
Results for the short-term toxicity to aquatic invertebrates of the substance (CAS no. 29340-81-6), were based on results of the dissociation product CAS no. 29340-81-6, namely triethanolamine (TEA, CAS no. 102-71-6) and structural analogue 2-hydroxypropyl)ammonium citrate (MIPA citrate; CAS no. 30798-32-4). For these substances, short-term toxicity guideline studies are available for aquatic invertebrates. The 48-h EC50 value for TEA in Daphnia magna is 609.88 mg/L (Warne et al., 1999), the 48-h EC50 value for MIPA citrate in Daphnia magna is > 100 mg/L (Charles River Laboratories, 2017). The lowest value of 100 mg/L will be used in the assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
No substance-specific data on theshort-term toxicity to aquatic invertebratesof the substance (CAS 29340-81-6) are available. However, according to Article 13 of legislation EC1907/2006, in case no appropriate animal studies are available for assessment, information should be generated whenever possible by means other than vertebrate animal tests, i. e. applying alternative methods such as in vitro tests, QSARs, grouping and read-across. CAS 29340-81-6 is an organic compound manufactured from triethanolamine (TEA, CAS 102-71-6) and citric acid (CAS 77-92-9) and dissociates into the respective TEA cation and citrate anion. Therefore it is considered to be acceptable to derive lacking information on toxicological properties of CAS 29340-81-6 by read-across from TEA and close analogue2-hydroxypropyl)ammonium citrate (MIPA citrate; CAS no. 30798-32-4), which dissociates into citric acid in water.
For TEA, the short-term toxicity to aquatic invertebrates was determined in a study according to ASTM Designation E1192 (GLP not specified)(Warne et al., 1999). In this study, groups of 15 daphnids per concentration (Ceriodaphnia dubia) were exposed for 48 hours to the test substance (concentration unknown) under static conditions. The number of immobile daphnids were counted at the end of test. The EC50 value after 48 hours in this study was determined to be 609.88 mg/L (95% CI: 565.5 - 658.3 mg/L).
For MIPA citrate, the acute toxicity to aquatic invertebrates was determined in a study according to OECD TG 202 and in compliance with GLP criteria (Ibacon, 2017). In this study daphnids (D. magna, 20 per concentration) were exposed to nominal concentrations of 0 (control) and 149 mg test item/L for 48 hours under static condition. The test material as such exists as aqueous solution: the test material concentration corresponds to a nominal concentration of 100 mg/L based on active ingredient (a.i.). Analytical confirmation of nominal test concentrations showed that all test concentrations remained well within ± 20% of nominal concentrations throughout the test. Therefore, effect concentrations are expressed as nominal. Immobilization was recorded after 24 and 48 hours exposure. No immobilisation of the test animals was observed in the control nor in the only test concentration of 100 mg a.i./L. Based on these findings the 48-h EC50 value was determined at > 100 mg a.i./L.
As a worst-case approach, the 48-h EC50 value of 100 mg/L is used in the derivation of PNECs of TEA citrate.
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