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EC number: 613-816-2 | CAS number: 6553-64-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In accordance with Regulation EC No. 1272/2008, the test substance has to be classified in Category 1B. Hazard statement “H314: Causes severe skin burns and eye damage” with signal word “Danger” are required.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 February to 14 March 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Study conducted in compliance with OECD 404 without any deviation and not under GLP
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Gérome, Quartier Labaste - 40260 Linxe, France
- Weight at study initiation: 2.50-2.90 kg
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 19-23°C
- Humidity: 30-49% - Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 1 hour
- Observation period:
- Obervation at 1, 24, 48 and 72h after the removal of the patch.
- Number of animals:
- In view of skin effects observed in the first animal treated, the two others were not treated.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48 h
- Score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3.5
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- At 24 hours, a severe erythema and a moderate oedema were observed. They were totally reversible from Day 5 of the study.
At Day 4, a scab was observed on the treated site until the end of the observation period. - Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- In accordance with Regulation EC No. 1272/2008, the test substance has to be classified in Category 1B. Hazard statement “H314: Causes severe skin burns and eye damage” with signal word “Danger” are required.
- Executive summary:
An in vivo skin irritation test on rabbit was conducted to predict the acute skin irritation potential of the test substance according to Guideline OECD 404.
The test substance was applied in one rabbit. 24h after the application, a severe erythema couple with a moderate edema were observed. This reactions were totally reversibles after 5 days. At day 4, the formation of a scab on the treated site was observed. This scab was noted until the end of the observation period.
Therefore, in accordance with Regulation EC No. 1272/2008, the test substance has to be classified in Category 1B “ Causes severe skin burns and eye damage”. Hazard statement “H314: Causes severe skin burns and eye damage” with signal word “Danger” are required.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
An in vivo skin irritation test on rabbit was conducted to predict the acute skin irritation potential of the test substanceaccording to Guideline OECD 404.
The test substance was applied in one rabbit. 24h after the application, a severe erythema couple with a moderate edema were observed. This reactions were totally reversibles after 5 days. At day 4, the formation of a scab on the treated site was observed. This scab was noted until the end of the observation period.
Justification for classification or non-classification
In accordance with Regulation EC No. 1272/2008, the test substance has to be classified in Category 1B. Hazard statement “H314: Causes severe skin burns and eye damage” with signal word “Danger” are required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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