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EC number: 233-514-0 | CAS number: 10210-68-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed database
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Dicobalt octacarbonyl
- Author:
- GESTIS
- Year:
- 2 017
- Bibliographic source:
- http://gestis-en.itrust.de/nxt/gateway.dll?f=templates$fn=default.htm$vid=gestiseng:sdbeng
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not specified in database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Octacarbonyldicobalt
- EC Number:
- 233-514-0
- EC Name:
- Octacarbonyldicobalt
- Cas Number:
- 10210-68-1
- Molecular formula:
- C8O8Co2
- IUPAC Name:
- 1,1,1,3,3,3-hexakis(oxidaniumylidynemethyl)-2,4-dioxo-1,3-dicobaltabicyclo[1.1.0]butane-1,1,3,3-tetrakis(ylium)
Constituent 1
Test animals
- Species:
- other: rats and mice
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- other: TDLo
- Remarks:
- lowest published toxic dose
- Effect level:
- 3 468 other: mg/kg bw
- Remarks on result:
- other: Initial toxic effects occurred following a total dose of 3468 mg/kg bw. Damage to the heart muscle, metabolic disturbances (hyperglycemia) and changes to the blood composition (changes to the erythrocyte count) were observed.
Target system / organ toxicity
- Key result
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 3 468 other: mg/kg bw
- System:
- other: cardiac, endocrine, blood
- Organ:
- other: Damage to the heart muscle, metabolic disturbances (hyperglycemia) and changes to the blood composition (changes to the erythrocyte count) were observed.
- Treatment related:
- not specified
- Dose response relationship:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Initial toxic effects occurred following a total dose of 3468 mg/kg bw. Damage to the heart muscle, metabolic disturbances (hyperglycemia) and changes to the blood composition (changes to the erythrocyte count) were observed.
- Executive summary:
There is no available information on the methods used to determine the value for this endpoint. However, this information is taken from GESTIS database which is considered to be a reliable peer reviewed database. There it is reported that no experience reports on the consequences of repeated exposure to D. are available from occupational handling.
Even from animal experiments there are no data concerning occupationally relevant exposure pathways.
Based on the acute symptoms observed on persons exposed and in animal experiments, inflammatory changes are also to be expected following long-term exposure to D.
By comparison, it is not possible to estimate whether or not Co-conditioned damage to the lung parenchyma (lung fibrosis), particularly observed following exposure to Co dust (principally as hard metal dust), can also occur following exposure to Co carbonyles.
The only indications of systemic cumulative effects to date are derived from a subacute experiment on rats and mice: The animals received D. in oral doses corresponding to 5 - 20 % of the LD50 for 23 days. Initial toxic effects occurred following a total dose of 3468 mg/kg bw. Damage to the heart muscle, metabolic disturbances (hyperglycemia) and changes to the blood composition (changes to the erythrocyte count) were observed.
Although further examination is needed, for the present the findings indicate that in principle D. can produce similar effects as other inorganic Co compounds.
For these compounds, damage to the heart muscle, increased erythropoiesis or polycythemia as well as hypofunction of the thyroid gland were the most significant systemic effects found following prolonged (mostly oral) intake of high doses.
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