Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-146-3 | CAS number: 3012-65-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The fate of diammonium hydrogen citrate in the environment is most accurately evaluated by separately assessing the fate of its moieties ammonium and citrate. In the assessment of environmental fate and behaviour of diammonium hydrogen citrate, available data indicate that ammonium and citrate are readily biodegradable. Hence, diammonium hydrogen citrate is also expected to be readily biodegradable.
Ammonium is not persistent in water. Available evidence points to a ready biodegradability of ammonium under aerobic conditions.
Citrate in the form of citric acid is ready biodegradable according to studies of biodegradation in water and sewage sludge and QSAR-based estimates.
Additional information
The fate and toxicity of diammonium hydrogen citrate in the environment is most accurately evaluated by separately assessing the fate of its moieties “ammonium (NH3, NH4+)” and “citrate”.
Read-across approach
Diammonium hydrogen citrate consists of two ammonium [NH4]+ ions and one hydrogen citrate ion [C6H6O7]2-. Based on the solubility of diammonium hydrogen citrate in water (1,000 g/L at 20°C), a complete dissociation of diammonium hydrogen citrate, resulting in ammonium (NH4+) and (hydrogen)citrate, may be assumed.
In aquatic and terrestrial environments, ionic ammonium (NH4+) is in equilibrium with ammonia (NH3), and the respective speciation is influenced by various parameters, including temperature, pH, salinity and ionic strength. The main factors, however, that influence the equilibrium between un-ionized and ionized ammonia are pH and temperature (Environment Canada 2010 and references therein). Raising pH by one unit can cause the un-ionized ammonia concentration to increase nearly tenfold, while a 5 °C temperature increase can cause an increase of 40-50% (Environment Canada 2010 and references therein). The ionic strength of the water is also an important influence on the un-ionized ammonia concentration. As the ionic strength increases in hard or marine waters, there is a decrease in the un-ionized NH3 concentration (Environment Canada 2010 and references therein). Ammonia (NH3) and ionic ammonium (NH4+) are referred to as total ammonia nitrogen (TAN).
With pKa values of 3.13, 4.76, and 6.4, citric acid is expected to be present as citrate ion [C6H5O7]3- or hydrogen citrate ion [C6H6O7]2- under environmentally relevant conditions.
Thus, under environmentally relevant conditions, ammonium (NH4+) and (hydrogen)citrate are expected to be present in ionic form and rather mobile.
Reference:
Environment Canada (2010). Canadian Council of Ministers of the Environment. Canadian water quality guidelines for the protection of aquatic life: Ammonia. In: Canadian environmental quality guidelines, 1999, Canadian Council of Ministers of the Environment, Winnipeg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.