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EC number: 412-830-4 | CAS number: 1823-59-2 ODPA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-10-30 to 2019-01-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Remarks:
- TOC measurements
- Details on sampling:
- - Concentrations: control and 100 mg/L
- Sampling method: sampling from test solutions without fish in intervals of 24h
- Sample storage conditions before analysis: refrigerated until transfer to analytical lab - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
The test item has a low water solubility and is hydrologically unstable, therefore a degraded solution of the test item was prepared before application based on OECD Series on Testing and Assessment No. 23.
- Method: The necessary amounts of test item for preparing the stock solutions were weighed and transferred to separate Schott bottles for each test item loading rate. These bottles were filled with 1.5 L of test medium and these solutions were stirred at room temperature in the dark for 24 hours. Afterwards the undissolved test item was allowed to sediment and/or float for a period of one and a half hours. The solutions were withdrawn from the middle of the vessel using a Teflon tube. Transfer of undissolved test item was avoided. For each test concentration, a separate solution was prepared to achieve the corresponding nominal concentration. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Strain: Danio rerio Hamilton (Cypriniformes: Cyprinidae)
- Source: University of Heidelberg Germany
- Length at study initiation: between 1 and 3 cm
- Food during culturing: commercial fish flake food and protein-enriched pellet food once per day
ACCLIMATION
- Acclimation period: none
FEEDING DURING TEST
- Food type: None - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 10° dH
- Test temperature:
- 25
- pH:
- 7.3
- Dissolved oxygen:
- 85%
- Conductivity:
- 426 µS/cm
- Nominal and measured concentrations:
- 0 and 100 mg/L
Meausured as TOC: 28 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 2L glass vessels
- Type : open
- Material, size, headspace, fill volume: 1.5L
- Aeration: No
- No. of organisms per vessel: 7 for control and 100 mg/L
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted test water
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours daily
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Interval: 0, 4, 24, 48, 72 and 96h
- observations: movement, loss of equilibrium, swimming behaviour, respiratory function, pigmentation and all other observed events
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not applicable - limit test
- Range finding study: At the same time of the limit test a range finding study was conducted with test concentrations 1 and 10 mg/L
No mortality was observed at these concentrations. - Reference substance (positive control):
- yes
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 28 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- other: TOC
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 28 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- other: TOC
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: None
- Observations on body length and weight: no difference in body length and weight between control and 100 mg/L test solution
- Other biological observations: none
- Mortality of control: no mortality in control
- Other adverse effects control: no adverse effects in control
- Abnormal responses: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: Precipitation was observed in the 100 mg/L test solution. - Results with reference substance (positive control):
- not reported
- Sublethal observations / clinical signs:
Determination of test item concentrations by TOC measurement:
Test item nominal (mg/L) TOC content nominal (mg/L) Sampling TOC found Geometric mean (%) Actual test item conc. (mg/L) [mg/L] % of nominal Control 0 0 h fresh 1.26 - - - 96 h aged 0.91 - 100 51.3 0 h fresh 15.7 28 28 28 96 h aged 16 29 - Validity criteria fulfilled:
- yes
- Conclusions:
- The toxicity of ODPA to fish (Danio rerio) was assessed in a 96h study according to OECD 203. The test material was found to be not toxic up to concentration 100 mg/L (nominal). No mortality or other signs of toxicity were observed.
- Executive summary:
The toxicity of ODPA to fish (Danio rerio) was assessed in a study according to OECD 203. Fish were exposed for 96h to a concentration having 100 mg/L nominal test concentration. Since the substance is not hydrolytically stable, test solutions were prepared by weighing the nominal test amount, and stirring the solution for 24h in the dark. Test were then performed with the resulting aged solution. A TOC measurement was performed and 28 mg/L test material appeared to be dissolved in the resulting solution. This test concentration was maintained throughout the study.
No signs of toxicity or mortality has been observed in the control or the test solutoin (100 mg/L). As a result, the effect levels of ODPA on fish are: NOEC = 100 mg/L (nominal) = 28 mg/L (TOC measurement) and EC50 > 100 mg/L (nominal) or > 28 mg/L (TOC measurement).
Reference
Description of key information
There is one study available in which the toxicity of ODPA to fish (Danio rerio) was assessed. This is in a study conducted in 2018 -2019 according to OECD 203. Fish were exposed for 96h to a concentration having 100 mg/L nominal test concentration. Since the substance is not hydrolytically stable, test solutions were prepared by weighing the nominal test amount, and stirring the solution for 24h in the dark. Test were then performed with the resulting aged solution. A TOC measurement was performed and 28 mg/L test material appeared to be dissolved in the resulting solution. This test concentration was maintained throughout the study.
No signs of toxicity or mortality has been observed in the control or the test solutoin (100 mg/L). As a result, the effect levels of ODPA on fish are: NOEC = 100 mg/L (nominal) = 28 mg/L (TOC measurement) and EC50 > 100 mg/L (nominal) or > 28 mg/L (TOC measurement).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 28 mg/L
Additional information
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