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Diss Factsheets
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EC number: 812-963-1 | CAS number: 178436-06-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 1995-01-03 and 1995-01-19
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- only basic data given; experimental period only 8 days; only 4 animals tested
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- experimental period 8 days only, only 4 animals tested
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Ceramide IIIB
- IUPAC Name:
- Ceramide IIIB
- Test material form:
- solid: particulate/powder
- Details on test material:
- Ceramide IIIB
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no information available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- propylene glycol
- Details on dermal exposure:
- no information given
- Duration of exposure:
- no information given
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 2 males and 2 females
- Control animals:
- not specified
- Details on study design:
- One group of Wistar rats, consisting of two males and two females, received a single dermal application of the test substance suspended in propylene glycol at a dose level of 2000 mg/kg body weight (dose volume 10 mL/kg body weight).
Animals were subjected to daily observations and determination of body weight at start and termination.
Macroscopic examination of the animals was performed at the end of the experimental period (day 8).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No clinical signs were observed.
- Gross pathology:
- No abnormalities were found at macroscopic examination of the animals.
- Other findings:
- None described.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to this study, the dermal LD50 value of the test substance for both males and females was considered to exceed 2000 mg/kg body weight.
- Executive summary:
In an acute dermal toxicity study similar to OECD guideline 402, 2 male and 2 female Wistar strain rats were given a single dose of Ceramide IIIB suspended in propylene glycol at a dose level of 2000 mg/kg body weight (dose volume 10 mL/kg body weight). Animals were subjected to daily observations and determination of body weight at start and termination. Macroscopic examination of the animals was performed at the end of the experimental period (day 8).
No animal died. No effect on body weight gain was observed. No clinical signs were observed during the study period and no macroscopic toxicological significant abnormalities were noted at necropsy at the end of the experimental period.
Dermal LD50 (rat) > 2000 mg/kg bw
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