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Diss Factsheets
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EC number: 210-498-3 | CAS number: 616-91-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Table 1: Overview of published results of repeated dose studies (subacute)
Source |
Species |
Route of exposure |
Duration |
Concentration |
Toxicologist 44,160, 2005 |
Rat |
Oral |
30 days |
TDLo |
Toxicologist 78, 212, 2004 |
Rat |
Oral |
30 days |
TDLo |
International Journal of Toxicology 23, 239, 2004 |
Rat |
Oral |
30 days |
TDLo |
Archives of Toxicology 79, 531, 2005 |
Rat |
Oral |
4 weeks |
TDLo |
European Journal of Pharmacology 519, 118, 2005 |
Rat |
Oral |
3 weeks |
TDLo |
European Journal of Pharmacology 543, 151, 2005 |
Rat |
Oral |
30 days |
7.5 mg/kg |
European Journal of Pharmacology 544, 118, 2006 |
Rat |
Oral |
8 weeks |
80640 mg/kg |
Toxicology 219, 197, 2006 |
Rat |
Oral |
21 days |
TDLo |
Neurotoxicology 28, 83, 2007 |
Rat |
Oral |
14 days |
TDLo |
Toxicology 243, 317, 2008 |
Rat |
Oral |
22 days |
TDLo |
Toxicology 243, 207, 2008 |
Rat |
Oral |
22 days |
TDLo |
Carcinogenesis 26, 657, 2005 |
Mouse |
Oral |
42 days |
4.2E+5 mg/kg |
Brazilian Journal of Medical and Biological Research 41, 765, 2008 |
Rat |
Oral |
28 days |
TDLo |
British Journal of Pharmacology 154, 136, 2008 |
Rat |
Oral |
7 days |
TDLo |
Human & Experimental Toxicology 28, 221, 2009 |
Rat |
Oral |
4 weeks |
TDLo |
Fundamental & Clinical Pharmacology 20, 247, 2006 |
Rat |
Oral |
8 days |
TDLo |
Clinical and Experimental Pharmacology and Physiology 35, 979, 2008 |
Rat |
Oral |
15 days |
TDLo |
Carcinogenesis 30, 1008, 2009 |
Rat |
Dermal |
4 weeks |
TDLo |
Food and Chemical Toxicology 49, 1404, 2011 |
Rat |
Oral |
28 days |
TDLo 2800 mg/kg |
L. BONANOMI, A. GAZZANIGA. Toxicological, Pharmacokinetic and Metabolic Studies on Acetylcysteine. Eur J Respir Dis (1980) 61, Suppl. 111, 45-51 |
Rat /Dog |
Oral |
4, 12, 28 or 52 days |
max. 300 - 2000 mg/kg No effects observed |
Acker-Mills, B. et al. Effects of N-Acetylcysteine on Thresholds and Otoacoustic Emissions Following Noise Exposure. Conference paper. 2005(19):00057 NTIS Order Number: ADA433105/XAB |
Rat |
Oral |
30 days |
600 oder 1200 mg/kg bw/d histopathology: no effects, ALT, GST activity and tissue GSH elevated |
Petersone, I. et al. Toxicological study of the mucolytic substance N-acety-L-cysteine. Eksperimental'naya i Klinicheskaya Farmakoterapiya (1972), No. 3, 5-15 CODEN: EKFMA7; ISSN: 0367-0589 |
Rat |
Oral |
1 month |
100, 500 and 1000 mg/kg/d |
Arfsten, D. et al. Impact of 30-day oral dosing with N-acety-L-cysteine on Sprague-Dawley rat physiology. International journal of toxicology, (2004 Jul-Aug) Vol. 23, No. 4, pp. 239-47. Journal code: 9708436. ISSN: 1091-5818. L-ISSN: 1091-5818. |
Rat |
Oral |
30 days |
|
Table 2: Overview of published results of repeated dose studies (subchronic)
Source |
Species |
Route of exposure |
Duration |
Concentration |
Phytomedicine 20, 828, 2013 |
Rat |
Oral |
12 weeks |
2100 mg/kg |
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.